{"id":3759,"date":"2025-03-31T18:11:49","date_gmt":"2025-03-31T18:11:49","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/busulfan-txt\/"},"modified":"2025-03-31T18:11:49","modified_gmt":"2025-03-31T18:11:49","slug":"busulfan-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/busulfan-txt\/","title":{"rendered":"Busulfan.txt"},"content":{"rendered":"

Busulfan<\/h1>\n

CLINICAL USE <\/H3><\/p>\n
  • Chronic myeloid leukaemia Remission of polycythaemia vera\n
  • Essential thrombocythaemia and myelofibrosis\n
  • Conditioning before bone marrow transplantation

    DOSE IN NORMAL RENAL FUNCTION <\/H3>Oral:\n
  • Chronic myeloid leukaemia: 60 mcg\/kg daily (maximum 4 mg daily); maintenance: 0.5\u20132 mg daily\n
  • Polycythaemia vera: 4\u20136 mg daily; maintenance: 2\u20133 mg daily\n
  • Myelofibrosis: 2\u20134 mg daily

    IV infusion <\/H4>
    \nConditioning before bone marrow transplantation: 0.8 mg\/kg every 6 hours over 4 days for 16 doses

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :246.3<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :7\u201332<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 1\u20132<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.62\u20130.85<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Antibacterials: concentration increased by metronidazole\n
  • Antipsychotics: avoid concomitant use with clozapine, increased risk of agranulocytosis\n
  • Antifungals: metabolism inhibited by itraconazole, monitor for signs of busulfan toxicity

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral,

    IV infusion <\/H4>

    Rate of Administration <\/H4>Over 2 hours

    Comments<\/H4>Dilute the solution to 500 mcg\/mL with sodium chloride or glucose 5%Give via a central venous catheter

    OTHER INFORMATION <\/H4>\n
  • Can cause haemorrhagic cystitis\n
  • Can cause an increase in creatinine and haematuria.
    \n","protected":false},"excerpt":{"rendered":"

    Busulfan CLINICAL USE Chronic myeloid leukaemia Remission of polycythaemia vera<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3759","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3759"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3759\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}