{"id":3754,"date":"2025-03-31T18:11:49","date_gmt":"2025-03-31T18:11:49","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/budesonide-txt\/"},"modified":"2025-03-31T18:11:49","modified_gmt":"2025-03-31T18:11:49","slug":"budesonide-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/budesonide-txt\/","title":{"rendered":"Budesonide.txt"},"content":{"rendered":"

Budesonide<\/h1>\n

CLINICAL USE <\/H3><\/p>\n
  • Asthma\n
  • Allergic and vasomotor rhinitis\n
  • Inflammatory skin disorders

    DOSE IN NORMAL RENAL FUNCTION <\/H3>Inhaler\/Turbohaler: 200\u20131600 micrograms daily in divided doses\n
  • Respules: 1\u20132 mg twice daily; half doses for maintenance\n
  • Nasal spray: 100 micrograms each nostril twice daily or 200 micrograms each nostril once daily; reduce to 100 micrograms each nostril once daily when symptoms controlled\n
  • Topical preparations: apply 1\u20132 times daily\n
  • Capsules: 3 mg, 3 times a day, CR: 9 mg once dailycinEnema: 2 mg\/100 mL at bedtime

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :430.5<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :85\u201390<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 0<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :3<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1.8\u20132.2 (inhaled), 3\u20134 (oral)\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Antifungals: concentration of inhaled budesonide increased by itraconazole and ketoconazole\n
  • Antivirals: concentration of inhaled and intranasal budesonide increased by ritonavir

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Respules: may be diluted up to 50% with sterile sodium chloride 0.9%

    Route <\/H4>Inhalation, topical, oral

    Rate of Administration <\/H4> \u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Special care is needed in patients with quiescent lung tuberculosis, fungal and viral infections in the airways.
    \n","protected":false},"excerpt":{"rendered":"

    Budesonide CLINICAL USE Asthma Allergic and vasomotor rhinitis Inflammatory skin<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3754","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3754"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3754\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}