{"id":3753,"date":"2025-03-31T18:11:49","date_gmt":"2025-03-31T18:11:49","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/bromocriptine-txt\/"},"modified":"2025-03-31T18:11:49","modified_gmt":"2025-03-31T18:11:49","slug":"bromocriptine-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/bromocriptine-txt\/","title":{"rendered":"Bromocriptine.txt"},"content":{"rendered":"

Bromocriptine<\/h1>\n

CLINICAL USE <\/H3><\/p>\n
  • Parkinsonism (but not drug-induced extrapyramidal symptoms)\n
  • Endocrine disorders

    DOSE IN NORMAL RENAL FUNCTION <\/H3>\n
  • Parkinson\u2019s disease: Week 1: 1\u20131.25 mg at night \u2014Week 2: 2\u20132.5 mg at night \u2014Week 3: 2.5 mg twice daily \u2014Week 4: 2.5 mg, 3 times daily \u2014then increasing by 2.5 mg every \u20143\u201314 days according to response \u2013 usual range 10\u201340 mg daily\n
  • Hypogonadism\/galactorrhoea, infertility: 1\u20131.25 mg at night, increased gradually; usual dose 7.5 mg daily in divided doses (maximum 30 mg daily); infertility without hyperprolactinaemia: 2.5 mg twice daily\n
  • Cyclical benign breast disease and cyclical menstrual disorders: 1\u20131.25 mg at night increased gradually; usual dose 2.5 mg twice daily\n
  • Acromegaly: 1\u20131.25 mg at night increased gradually to 5 mg every 6 hours\n
  • Prolactinoma: 1\u20131.25 mg at night increased gradually to 5 mg every 6 hours (maximum 30 mg daily)

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :750.7 (as mesilate)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :90\u201396<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 2.5\u20135.5<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :1\u20133<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :8\u201320\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsIncreased risk of toxicity with bromocriptine and isometheptene or phenylpropanolamine

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Take with food

    OTHER INFORMATION <\/H4>\n
  • Hypotensive reactions may occur during the first few days of treatment. Tolerance may be reduced by alcoholDigital vasospasm can occur\n
  • Concomitant administration of macrolide antibiotics may elevate bromocriptine levels.
    \n","protected":false},"excerpt":{"rendered":"

    Bromocriptine CLINICAL USE Parkinsonism (but not drug-induced extrapyramidal symptoms) Endocrine<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3753","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3753"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3753\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}