{"id":3742,"date":"2025-03-31T18:11:48","date_gmt":"2025-03-31T18:11:48","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/betaxolol-hydrochloride-txt\/"},"modified":"2025-03-31T18:11:48","modified_gmt":"2025-03-31T18:11:48","slug":"betaxolol-hydrochloride-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/betaxolol-hydrochloride-txt\/","title":{"rendered":"Betaxolol hydrochloride.txt"},"content":{"rendered":"

Betaxolol hydrochloride<\/h1>\n

CLINICAL USE <\/H3>
\nHyperlipidaemia

DOSE IN NORMAL RENAL FUNCTION <\/H3>200 mg, 3 times a day Modified release: 400 mg daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :361.8<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :95<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 50<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.24\u20130.35<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1\u20132 (XL: 3.4)\/7.8\u201320

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>40\u201360 400 mg daily15\u201340 200 mg every 24\u201348 hours<15 Avoid

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. 200 mg every 72 hours<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. 200 mg every 72 hours
  • HDF\/high flux &nbsp :Unknown dialysability. 200 mg every 72 hours
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR=15\u201340 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAntibacterials: increased risk of myopathy with daptomycin \u2013 try to avoid concomitant useAnticoagulants: enhances effect of coumarins and phenindione; dose of anticoagulant should be reduced by up to 50% and adjusted by monitoring INRAntidiabetics: may improve glucose tolerance and have an additive effect with insulin or sulphonylureasCiclosporin: may increase nephrotoxicity and reduce ciclosporin levelsLipid-regulating drugs: increased risk of myopathy in combination with statins and ezetimibe \u2013 avoid with ezetimibe; do not exceed 10 mg of simvastatin1

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Take dose with or after food Contraindicated in nephrotic syndrome There should be an interval of 2 hours between intake of ion exchange resin and bezafibrateModified-release preparation is not appropriate in renal impairment
    \n","protected":false},"excerpt":{"rendered":"

    Betaxolol hydrochloride CLINICAL USE Hyperlipidaemia DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3742","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3742"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3742\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}