{"id":3739,"date":"2025-03-31T18:11:48","date_gmt":"2025-03-31T18:11:48","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/benzylpenicillin-txt\/"},"modified":"2025-03-31T18:11:48","modified_gmt":"2025-03-31T18:11:48","slug":"benzylpenicillin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/benzylpenicillin-txt\/","title":{"rendered":"Benzylpenicillin.txt"},"content":{"rendered":"

Benzylpenicillin<\/h1>\n

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>2.4\u201314.4 g daily in 4\u20136 divided doses

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :334.4<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :60<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 60\u201390<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.3\u20130.42<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :0.5\/10

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : 600 mg \u2013 2.4 g every 6 hours depending on severity of infection
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 600 mg \u2013 1.2 g every 6 hours depending on severity of infection

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsReduced excretion of methotrexate

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\n
  • IV Bolus: 600 mg in 5 mL water for injectionIV Infusion: 600 mg in at least 10 mL sodium chloride 0.9%\n
  • IM: 600 mg in 1.6 mL water for injection 600 mg displaces 0.4 mL

    Route <\/H4>IV Bolus, IV Infusion, IM

    Rate of Administration <\/H4>IV bolus: over 3\u20134 minutes

    IV infusion <\/H4>: over 30\u201360 minutes

    Comments<\/H4>IV doses in excess of 1.2 g must be given slowly at minimum rate of 300 mg\/minute

    OTHER INFORMATION <\/H4>\n
  • Dose in normal renal function: meningitis up to 14.4 g daily; bacterial endocarditis 4.8 g daily\n
  • Maximum dose in severe renal impairment: 4.8 g per day600 mg of benzylpenicillin sodium (1 mega unit) contains 1.68 mmol of sodium600 mg of benzylpenicillin potassium contains 1.7 mmol potassium\n
  • Increased incidence of neurotoxicity in renal impairment (seizures)\n
  • False positive urinary protein reactions may be caused by benzylpenicillin therapy
    \n","protected":false},"excerpt":{"rendered":"

    Benzylpenicillin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3739","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3739"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3739\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3739"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3739"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}