{"id":3712,"date":"2025-03-31T18:11:48","date_gmt":"2025-03-31T18:11:48","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/aztreonam-txt\/"},"modified":"2025-03-31T18:11:48","modified_gmt":"2025-03-31T18:11:48","slug":"aztreonam-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/aztreonam-txt\/","title":{"rendered":"Aztreonam.txt"},"content":{"rendered":"

Aztreonam<\/h1>\n

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3><\/p>\n
  • 1 g every 8 hours or 2 g every 12 hours\n
  • Severe infections: 2 g every 6\u20138 hours\n
  • UTI: 0.5\u20131 g every 8\u201312 hours

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :435.4<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :60<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 60\u201370<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.5\u20131<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1.7\/6\u20138

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>30\u201350 Dose as in normal renal function10\u201330 1\u20132 g loading dose, then maintenance of 50% of appropriate normal dose
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 1\u20132 g loading dose, then maintenance of 25% of appropriate normal dose

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Loading dose of 2 g then 1\u20132 g every 12 hours1,2 CVVhd\/HDFDialysed. 2 g every 12 hours2

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsPossibly enhanced anticoagulant effect of coumarins

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>3 mL of water for injection per 1 g vial

    Route <\/H4>IM, IV bolus,

    IV infusion <\/H4>

    Rate of Administration <\/H4>IM injection: Give by deep injection into a large muscle massIV: Slowly inject directly into the vein over a period of 3\u20135 minutes

    IV infusion <\/H4>: Give over 20\u201360 minutes

    Comments<\/H4>Suitable infusion solutions: glucose 5%, sodium chloride 0.9%, compound sodium lactateDilute to a concentration of not less than 20 mg\/mLOnce reconstituted aztreonam can be stored in a refrigerator for 24 hoursIV route recommended for single doses >1 g

    OTHER INFORMATION <\/H4>Manufacturers recommend that patients with renal impairment be given the usual initial dose followed by a maintenance dose adjusted according to creatinine clearance.\n
  • The normal dose interval should not be altered
    \n","protected":false},"excerpt":{"rendered":"

    Aztreonam CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3712","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3712"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3712\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}