{"id":3710,"date":"2025-03-31T18:11:48","date_gmt":"2025-03-31T18:11:48","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/azathioprine-txt\/"},"modified":"2025-03-31T18:11:48","modified_gmt":"2025-03-31T18:11:48","slug":"azathioprine-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/azathioprine-txt\/","title":{"rendered":"Azathioprine.txt"},"content":{"rendered":"

Azathioprine<\/h1>\n

CLINICAL USE <\/H3>
\nImmunosuppressive:<\/p>\n
  • Prophylaxis of transplant rejection\n
  • Treatment of various auto-immune conditions

    DOSE IN NORMAL RENAL FUNCTION <\/H3>1\u20135 mg\/kg\/day

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :277.3<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :<30<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <2<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.55\u20130.8<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3\u20135\/Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : 75\u2013100%
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 50\u2013100%

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Allopurinol: enhances effect with increased toxicity. Reduce azathioprine dose by 50\u201375% if administered concomitantly\n
  • Antibacterials: increased risk of haematological toxicity with co-trimoxazole\n
  • Anticoagulants: possibly reduced anticoagulant effect of coumarins\n
  • Antipsychotics: avoid concomitant use with clozapineCiclosporin: ?decreased ciclosporin absorption and bioavailability\n
  • Cytotoxic agents may be additive or synergistic in producing toxicity, particularly on the bone marrow

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Add 5 mL water for injection to each vial (50 mg)

    Route <\/H4>Oral, IV

    Rate of Administration <\/H4>Over not less than 1 minute

    Comments<\/H4>\n
  • Some units dilute to 100 mL sodium chloride or glucose 5% and infuse over 1 hour.\n
  • IV bolus peripherally, preferably in the side arm of a fast-running infusionVery irritant to veins. Flush with 50 mL sodium chloride 0.9% after administration\n
  • Take tablets with or after food

    OTHER INFORMATION <\/H4>Extensively metabolised to mercaptopurine\n
  • 1 mg by IV injection is equivalent to 1 mg by oral route\n
  • 6-mercaptopurine levels can be monitored in patients with low urate clearance\n
  • Monitor white cell and platelet counts\n
  • Cytotoxic Drug \u2013 Do Not Handle Can be given as an intermittent infusion (up to 250 mg in 100 mL)\n
  • About 40\u201360% is removed by haemodialysis.
    \n","protected":false},"excerpt":{"rendered":"

    Azathioprine CLINICAL USE Immunosuppressive: Prophylaxis of transplant rejection Treatment of<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3710","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3710"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3710\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}