{"id":3689,"date":"2025-03-31T18:11:47","date_gmt":"2025-03-31T18:11:47","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ampicillin2-txt\/"},"modified":"2025-03-31T18:11:47","modified_gmt":"2025-03-31T18:11:47","slug":"ampicillin2-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ampicillin2-txt\/","title":{"rendered":"Ampicillin2.txt"},"content":{"rendered":"

Ampicillin<\/h1>\n

CLINICAL USE <\/H3>
\nAntibacterial agent
\n

DOSE IN NORMAL RENAL FUNCTION <\/H3>
\nOral: 250 mg \u2013 1 g every 6 hours
\nIM\/IV: 500 mg \u2013 2 g every 4\u20136 hours
\n

PHARMACOKINETICS <\/H3>
\n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n349.4 <\/div>\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n20\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \nOral: 20\u201360;
    \nParenteral: 60\u201380\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \n0.17\u20130.31\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n1\u20131.5\/7\u201320
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
    \n
  • 10 to 20 &nbsp &nbsp : 250 mg \u2013 2 g every 6 hours
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n250 mg \u20131 g every 6 hours
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nNot dialysed. Dose as in
    \nGFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nDialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/
    \nmin
    \n
  • HDF\/high flux &nbsp :
    \nDialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/
    \nmin
    \n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nDialysed. Dose as in GFR=10\u2013
    \n20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3>
    \nPotentially hazardous interactions with other drugs
    \nCiclosporin: may increase ciclosporin <\/p>\n

    levels
    \nReduces excretion of methotrexate <\/p>\n

    (increased risk of toxicity)
    \n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4>
    \nUse water for injection: 5 mL for each <\/p>\n

    250 mg (1.5 mL for 250 mg or 500 mg for
    \nIM administration)
    \n

    Route <\/H4>
    \nOral, IV, IM<\/p>\n

    Rate of Administration <\/H4>
    \nSlow IV bolus over 3\u20134 minutes. Doses <\/p>\n

    greater than 500 mg should be given by
    \ninfusion
    \n

    Comments<\/H4>
    \nCan be diluted in glucose 5% or sodium <\/p>\n

    chloride 0.9%
    \n

    OTHER INFORMATION <\/H4><\/p>\n
  • Rashes more common in patients with\n

    renal impairment<\/p>\n

  • Can cause nephrotoxicity if dose not\n

    reduced in renal impairment<\/p>\n

  • Sodium content of injection\n

    1.47 mmol\/500 mg vial<\/p>\n

  • Ampicillin may be used in peritoneal\n

    dialysis fluids for treatment of peritonitis
    \nDo not mix with aminoglycosides<\/p>\n","protected":false},"excerpt":{"rendered":"

    Ampicillin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3689","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3689"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3689\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}