{"id":3686,"date":"2025-03-31T18:11:47","date_gmt":"2025-03-31T18:11:47","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/amoxicillin-txt\/"},"modified":"2025-03-31T18:11:47","modified_gmt":"2025-03-31T18:11:47","slug":"amoxicillin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/amoxicillin-txt\/","title":{"rendered":"Amoxicillin.txt"},"content":{"rendered":"

Amoxicillin<\/h1>\n

CLINICAL USE <\/H3>
\nAntibacterial agent
\n

DOSE IN NORMAL RENAL FUNCTION <\/H3>
\n250 mg \u2013 1 g every 8 hours (maximum 6 g per
\nday, up to 12 g in endocarditis)
\n

PHARMACOKINETICS <\/H3>
\n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n365.4\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n20\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \n60\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \n0.3\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n1\u20131.5\/7\u201320
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
    \n
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n250 mg \u2013 1 g every 8 hours
    \n(Maximum 6 g per day in
    \nendocarditis)
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nNot dialysed. Dose as in
    \nGFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nDialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/
    \nmin
    \n
  • HDF\/high flux &nbsp :
    \nDialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/
    \nmin
    \n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nDialysed. Dose as in normal renal
    \nfunction
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3>
    \nPotentially hazardous interactions with other drugs<\/p>\n
  • Amoxicillin can reduce the excretion of\n

    methotrexate (increased risk of toxicity)
    \n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4><\/p>\n
  • IV: Dissolve each 250 mg in 5 mL water for\n

    injection <\/p>\n

  • IV Infusion: Dilute in 100 mL glucose 5%\n

    or sodium chloride 0.9%<\/p>\n

  • IM: Dissolve 250 mg in 1.5 mL water for\n

    injection; 500 mg in 2.5 mL water for
    \ninjection; 1 g in 2.5 mL water for injection
    \nor 1% sterile lidocaine hydrochloride
    \n

    Route <\/H4>
    \nOral, IV, IM<\/p>\n

    Rate of Administration <\/H4><\/p>\n
  • Slow bolus IV over 3\u20134 minutes\n
  • Infusion over 30\u201360 minutes\n

    Comments<\/H4>
    \nStability in infusion depends upon diluent<\/p>\n

    OTHER INFORMATION <\/H4>
    \nSodium \u2013 3.3 mmol\/g vial of Amoxil<\/p>\n

    Do not mix with aminoglycosides<\/p>\n","protected":false},"excerpt":{"rendered":"

    Amoxicillin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3686","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3686"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3686\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}