{"id":3670,"date":"2025-03-31T18:11:47","date_gmt":"2025-03-31T18:11:47","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/alfacalcidol-txt\/"},"modified":"2025-03-31T18:11:47","modified_gmt":"2025-03-31T18:11:47","slug":"alfacalcidol-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/alfacalcidol-txt\/","title":{"rendered":"Alfacalcidol.txt"},"content":{"rendered":"

Alfacalcidol<\/h1>\n

CLINICAL USE <\/H3>
\nVitamin D analogue:<\/p>\n
  • Increase serum calcium levels\n
  • Inhibition of parathyroid hormone release\n
  • Suppression of PTH production\n

    DOSE IN NORMAL RENAL FUNCTION <\/H3>
    \n0.25\u20131 microgram daily according to
    \nresponseAlternatively, up to 4 micrograms 3
    \ntimes a week
    \n

    PHARMACOKINETICS <\/H3>
    \n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n400.6\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nExtensive plasma
    \nprotein binding\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \n13\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \nNo data\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n<3\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
    \n
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nDose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nNot dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nDialysed. Dose as in normal renal
    \nfunction
    \n
  • HDF\/high flux &nbsp :
    \nDialysed. Dose as in normal renal
    \nfunction
    \n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nNot dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3>
    \nPotentially hazardous interactions with other drugs<\/p>\n
  • Carbamazepine, phenytoin, phenobarbital\n

    and primidone may increase metabolism
    \nof alfacalcidol, necessitating larger doses
    \nthan normal to produce the desired effect
    \n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4>
    \n\u2013
    \n

    Route <\/H4>
    \nO, IV<\/p>\n

    Rate of Administration <\/H4>
    \nOver 30 seconds<\/p>\n

    Comments<\/H4>
    \n\u2013
    \n

    OTHER INFORMATION <\/H4><\/p>\n
  • Adjust dose according to responseSerum\n

    calcium ref range 2.1\u20132.6 mmol\/L (total)
    \nAn IV preparation (2 micrograms\/mL) and <\/p>\n

    an oral solution (2 micrograms\/mL) are
    \nalso available<\/p>\n

  • Doses of 1 microgram daily for 5 days\n

    may need to be given immediately prior
    \nto parathyroidectomy. Alternatively,
    \ngive 5 micrograms immediately prior to
    \nparathyroidectomy<\/p>\n

  • Capsules of One-Alfa (Leo) contain\n

    sesame oil<\/p>\n","protected":false},"excerpt":{"rendered":"

    Alfacalcidol CLINICAL USE Vitamin D analogue: Increase serum calcium levels<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3670","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3670","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3670"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3670\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}