{"id":3663,"date":"2025-03-31T18:11:46","date_gmt":"2025-03-31T18:11:46","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/acitretin-txt\/"},"modified":"2025-03-31T18:11:46","modified_gmt":"2025-03-31T18:11:46","slug":"acitretin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/acitretin-txt\/","title":{"rendered":"Acitretin.txt"},"content":{"rendered":"

Acitretin<\/h1>\n

CLINICAL USE <\/H3><\/p>\n
  • Severe extensive psoriasis, palmoplantar\n

    pustular psoriasis<\/p>\n

  • Severe congenital ichthyosis\n
  • Severe Darier\u2019s disease\n

    DOSE IN NORMAL RENAL FUNCTION <\/H3><\/p>\n
  • Initially: 25\u201330 mg daily (Darier\u2019s disease\n

    10 mg daily) for 2\u20134 weeks, adjusted
    \naccording to response<\/p>\n

  • Ongoing: usually 25\u201350 mg\/day\n

    (maximum 75 mg) for further 6\u20138 weeks.
    \n(In Darier\u2019s disease and ichthyosis not
    \nmore than 50 mg daily for up to 6 months)
    \n

    PHARMACOKINETICS <\/H3>
    \n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n326.4\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n>99 (< 0.1% present
    \nas unbound drug
    \nin pooled human
    \nplasma)\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \nExcreted as
    \nmetabolites\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \n9\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n50\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n
  • 20 to 50 &nbsp &nbsp : No data available. Assume dose as in
    \nnormal renal function
    \n
  • 10 to 20 &nbsp &nbsp : No data available. Assume dose as in
    \nnormal renal function
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nNo data available. Assume dose as in
    \nnormal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nNot dialysed. Dose as in normal renal function
    \n
  • HDF\/high flux &nbsp :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function
    \n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nUnknown dialysability. Dose as in
    \nnormal renal function
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3>
    \nPotentially hazardous interactions with other drugs<\/p>\n
  • Antibacterials: possibly increased risk of\n

    benign intracranial hypertension with
    \ntetracyclines \u2013 avoid concomitant use<\/p>\n

  • Anticoagulants: possible antagonism of the\n

    anticoagulant effect of coumarins<\/p>\n

  • Cytotoxics: increased concentration\n

    of methotrexate (also increased risk of
    \nhepatotoxicity) \u2013 avoid concomitant use
    \n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4>
    \n\u2013
    \n

    Route <\/H4>
    \nOral<\/p>\n

    Rate of Administration <\/H4>
    \n\u2013
    \n

    Comments<\/H4>
    \nTake once daily with meals or with milk<\/p>\n

    OTHER INFORMATION <\/H4>
    \nManufacturer\u2019s literature contraindicates <\/p>\n

    the use of acitretin in renal failure<\/p>\n","protected":false},"excerpt":{"rendered":"

    Acitretin CLINICAL USE Severe extensive psoriasis, palmoplantar pustular psoriasis Severe<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3663","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3663"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3663\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}