{"id":3662,"date":"2025-03-31T18:11:46","date_gmt":"2025-03-31T18:11:46","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/acipimox-txt\/"},"modified":"2025-03-31T18:11:46","modified_gmt":"2025-03-31T18:11:46","slug":"acipimox-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/acipimox-txt\/","title":{"rendered":"Acipimox.txt"},"content":{"rendered":"

Acipimox<\/h1>\n

CLINICAL USE <\/H3>
\nHyperlipidaemia
\n

DOSE IN NORMAL RENAL FUNCTION <\/H3>
\n250 mg 2 or 3 times daily
\n

PHARMACOKINETICS <\/H3>
\n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n154.1\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n0\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \n86\u201390\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \n0.3\u20130.4\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n2\/Increased
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n40\u201380 250 mg daily
    \n20\u201340 250 mg alternate days.
    \n<20
    \nSee \u2018Other Information\u2019
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nLikely dialysability. Dose as in
    \nGFR<20 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nDialysed. Dose as in
    \nGFR<20 mL\/min
    \n
  • HDF\/high flux &nbsp :
    \nDialysed. Dose as in
    \nGFR<20 mL\/min
    \n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nDialysed. Dose as in
    \nGFR=20\u201340 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3>
    \nPotentially hazardous interactions with other drugs<\/p>\n
  • None known\n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4>
    \n\u2013
    \n

    Route <\/H4>
    \nOral<\/p>\n

    Rate of Administration <\/H4>
    \n\u2013
    \n

    Comments<\/H4>
    \nTake with or after meals<\/p>\n

    OTHER INFORMATION <\/H4><\/p>\n
  • Females are twice as likely as males to\n

    suffer from side effects, e.g. flushing,
    \npruritus and skin rashes<\/p>\n

  • Doses up to 1200 mg have been given\n

    safely for long periods
    \nAfter a 5 hour dialysis 70% of the drug had <\/p>\n

    been removed<\/p>\n

  • Dollery advises the doses given in the\n

    table, down to 20 mL\/minute, but nothing
    \nafter that.
    \nMicromedex gives the following <\/p>\n

    recommendations:
    \nGFR: 30\u201360 mL\/min 150 mg twice daily
    \nGFR: 10\u201330 mL\/min 150 mg once daily
    \nGFR:

  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min 150 mg alternate days<\/p>\n","protected":false},"excerpt":{"rendered":"

    Acipimox CLINICAL USE Hyperlipidaemia DOSE IN NORMAL RENAL FUNCTION 250<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3662","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3662"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3662\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}