{"id":3661,"date":"2025-03-31T18:11:46","date_gmt":"2025-03-31T18:11:46","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/aciclovir-oral-txt\/"},"modified":"2025-03-31T18:11:46","modified_gmt":"2025-03-31T18:11:46","slug":"aciclovir-oral-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/aciclovir-oral-txt\/","title":{"rendered":"Aciclovir oral.txt"},"content":{"rendered":"

Aciclovir oral<\/h1>\n

CLINICAL USE <\/H3>Antiviral agent:<\/p>\n
  • Herpes simplex and herpes zoster infection

    DOSE IN NORMAL RENAL FUNCTION <\/H3>\n
  • Simplex treatment: 200\u2013400 mg 5 times daily\n
  • Prophylaxis (immunocompromised): 200\u2013400 mg every 6 hours\n
  • Suppression: 200 mg every 6 hours, or 400 mg every 12 hours\n
  • Zoster: 800 mg 5 times a day for 7 days

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :225.2<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :9\u201333<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 40\u201370<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.7<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2.9\/19.5 (dialysis: 5.7)

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>25\u201350 Dose as in normal renal function 10\u201325 Simplex: 200 mg 3\u20134 times daily. Zoster: 800 mg every 8\u201312 hours
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Simplex: 200 mg every 12 hours. Zoster: 400\u2013800 mg every 12 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min. Give dose after dialysis
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min. Give dose after dialysis
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR=10\u201320 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Ciclosporin: reports of increase and decrease in ciclosporin levels; some editors report no experience of interaction locally; possibly increased risk of nephrotoxicity.\n
  • Higher plasma levels of aciclovir and mycophenolate mofetil with concomitant administration\n
  • Tacrolimus: possibly increased risk of nephrotoxicity

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Dispersible tablets may be dispersed in a minimum of 50 mL of water or swallowed whole with a little water

    OTHER INFORMATION <\/H4>\n
  • Consider IV therapy for herpes zoster infection if patient severely immunocompromised\n
  • Plasma aciclovir concentration is reduced by 60% during haemodialysis
    \n","protected":false},"excerpt":{"rendered":"

    Aciclovir oral CLINICAL USE Antiviral agent: Herpes simplex and herpes<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3661","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3661"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3661\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}