{"id":3658,"date":"2025-03-31T18:11:46","date_gmt":"2025-03-31T18:11:46","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/acetazolamide-txt\/"},"modified":"2025-03-31T18:11:46","modified_gmt":"2025-03-31T18:11:46","slug":"acetazolamide-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/acetazolamide-txt\/","title":{"rendered":"Acetazolamide.txt"},"content":{"rendered":"

Acetazolamide <\/h1>\n

CLINICAL USE <\/H3>Carbonic anhydrase inhibitor:<\/p>\n
  • Glaucoma\n
  • Diuretic\n
  • Epilepsy

    DOSE IN NORMAL RENAL FUNCTION <\/H3>Glaucoma\/Epilepsy: 0.25\u20131 g daily in divided dosesDiuretic: 250\u2013375 mg daily

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :222.2<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :70\u201390<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 100<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.2<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3\u20136\/26

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : 250 mg up to 4 times a day
  • 10 to 20 &nbsp &nbsp : 250 mg up to twice a day
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 250 mg daily

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely dialysability. Dose as in GFR <10 mL\/min.
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Analgesics: high dose aspirin reduces excretion (risk of toxicity)\n
  • Anti-arrhythmics: increased toxicity if hypokalaemia occursAntibacterials: effects of methenamine antagonised\n
  • Anti-epileptics: increased risk of osteomalacia with phenytoin, primidone and phenobarbital; concentration of carbamazepine increased and primidone reduced\n
  • Antihypertensives: enhanced hypotensive effect\n
  • Antipsychotics: increased risk of ventricular arrhythmias due to hypokalaemia\n
  • Atomoxetine: increased risk of ventricular arrhythmias due to hypokalaemia\n
  • Beta-blockers: increased risk of ventricular arrhythmias due to hypokalaemia with sotalol\n
  • Cardiac glycosides: increased toxicity if hypokalaemia occurs\n
  • Lithium: lithium excretion increased

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Add at least 5 mL of water for injection

    Route <\/H4>Oral, IM, IV

    Rate of Administration <\/H4>Give slow IV

    Comments<\/H4>Avoid IM due to alkaline pH Monitor for signs of extravasation and skin necrosis during administration

    OTHER INFORMATION <\/H4>\n
  • Use cautioned in severe renal failure\n
  • Acetazolamide sodium (Diamox) parenteral contains 2.36 millimoles of sodium per vial\n
  • Severe metabolic acidosis may occur in the elderly and in patients with reduced renal function
    \n","protected":false},"excerpt":{"rendered":"

    Acetazolamide CLINICAL USE Carbonic anhydrase inhibitor: Glaucoma Diuretic Epilepsy DOSE<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3658","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3658"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3658\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}