{"id":3654,"date":"2025-03-31T18:11:46","date_gmt":"2025-03-31T18:11:46","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/acarbose-txt\/"},"modified":"2025-03-31T18:11:46","modified_gmt":"2025-03-31T18:11:46","slug":"acarbose-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/acarbose-txt\/","title":{"rendered":"Acarbose.txt"},"content":{"rendered":"

Acarbose<\/h1>\n

CLINICAL USE <\/H3>
\nAntidiabetic agent
\n

DOSE IN NORMAL RENAL FUNCTION <\/H3>
\n50\u2013200 mg 3 times a day
\n

PHARMACOKINETICS <\/H3>
\n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n645.6\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n15\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \n1.7 (35% including
    \ninactive metabolites)\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \n0.32\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n3\u20139\/Increased
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n25\u201350 Dose as in normal renal function
    \n10\u201325 Avoid
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nAvoid
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nUnknown dialysability. Avoid<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nUnknown dialysability. Avoid. See
    \n\u2018Other Information\u2019
    \n
  • HDF\/high flux &nbsp :
    \nUnknown dialysability. Avoid. See
    \n\u2018Other Information\u2019
    \n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nUnknown dialysability. Avoid
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3>
    \nPotentially hazardous interactions with other drugs<\/p>\n
  • Antibacterials: hypoglycaemic effect\n

    possibly enhanced and increased
    \ngastrointestinal side effects with neomycin<\/p>\n

  • Lipid lowering agents: hypoglycaemic\n

    effect possibly enhanced by colestyramine
    \n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4>
    \n\u2013
    \n

    Route <\/H4>
    \nOral<\/p>\n

    Rate of Administration <\/H4>
    \n\u2013
    \n

    Comments<\/H4><\/p>\n

    OTHER INFORMATION <\/H4><\/p>\n
  • Only 1\u20132% of active drug is absorbed\n
  • In renal impairment, peak concentrations\n

    are 5 times higher than in the general
    \npopulation and the AUC is 6 times higher<\/p>\n

  • One paper records the use of acarbose\n

    in a haemodialysis patient who had
    \nundergone a total gastrectomy to treat
    \noxyhyperglycaemia: using a dose of
    \n100 mg before meals. <\/p>\n

    with food<\/p>\n","protected":false},"excerpt":{"rendered":"

    Acarbose CLINICAL USE Antidiabetic agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3654","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3654"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3654\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}