{"id":2295,"date":"2023-06-25T17:55:36","date_gmt":"2023-06-25T17:55:36","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/zopiclone\/"},"modified":"2023-06-25T18:00:56","modified_gmt":"2023-06-25T18:00:56","slug":"zopiclone","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/zopiclone\/","title":{"rendered":"Zopiclone"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Hypnotic<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

3.75\u20137.5 mg at night<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 388.8<\/li>\n
  • %Protein binding                           : 45\u201380<\/li>\n
  • %Excreted unchanged in urine     : <5<\/li>\n
  • Volume of distribution (L\/kg)       : 91.8\u2013104.6 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 3.5\u20136.5\/Unchanged
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Start with lower dose
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     : Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   : Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      : Dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: metabolism inhibited by erythromycin and quinupristin\/ dalfopristin; concentration significantly reduced by rifampicin<\/li>\n
  • Antipsychotics: enhanced sedative effects<\/li>\n
  • Antivirals: concentration possibly increased by ritonavir
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    It is recommended that elderly patients and those with severe renal disease should start treatment with 3.75 mg; however, accumulation has not been observed .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Hypnotic DOSE IN NORMAL RENAL FUNCTION 3.75\u20137.5 mg<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2295","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2295"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2295\/revisions"}],"predecessor-version":[{"id":2306,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2295\/revisions\/2306"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}