{"id":2292,"date":"2023-06-25T17:55:36","date_gmt":"2023-06-25T17:55:36","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/zolmitriptan\/"},"modified":"2023-06-25T18:01:18","modified_gmt":"2023-06-25T18:01:18","slug":"zolmitriptan","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/zolmitriptan\/","title":{"rendered":"Zolmitriptan"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Acute treatment of migraine<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

2.5\u20135 mg, repeated after 2 hours if required; maximum 10 mg in 24 hours<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 287.4<\/li>\n
  • %Protein binding                           : 25<\/li>\n
  • %Excreted unchanged in urine     : 60 (as metabolites)<\/li>\n
  • Volume of distribution (L\/kg)       : 2.4<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 2.5\u20133\/3\u20133.5
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HD                     : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: quinolones possibly inhibit metabolism \u2013 reduce dose of zolmitriptan<\/li>\n
  • Antidepressants: risk of CNS toxicity with MAOIs and moclobemide \u2013 reduce dose of zolmitriptan to max 7.5 mg; SSRIs inhibit metabolism of zolmitriptan; possibly increased serotonergic effects with duloxetine; increased serotonergic effects with St John\u2019s wort \u2013 avoid concomitant use Cimetidine: inhibits metabolism of zolmitriptan; maximum dose is 5 mg<\/li>\n
  • Ergot alkaloids: increased risk of vasospasm Linezolid: risk of CNS toxicity \u2013 reduce dose of zolmitriptan
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013 .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Acute treatment of migraine DOSE IN NORMAL RENAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2292","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2292"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2292\/revisions"}],"predecessor-version":[{"id":2309,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2292\/revisions\/2309"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}