{"id":2286,"date":"2023-06-25T17:55:36","date_gmt":"2023-06-25T17:55:36","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/xipamide\/"},"modified":"2023-06-25T18:01:12","modified_gmt":"2023-06-25T18:01:12","slug":"xipamide","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/xipamide\/","title":{"rendered":"Xipamide"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Thiazide diuretic: Hypertension Oedema<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Oedema: 40\u201380 mg in the morning Maintenance: 20 mg in the morning Hypertension: 20 mg in the morning<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 354.8<\/li>\n
  • %Protein binding                           : 99<\/li>\n
  • %Excreted unchanged in urine     : 50<\/li>\n
  • Volume of distribution (L\/kg)       : 10\u201321 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 5\u20138\/9\u201332
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HD                     : Dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Dialysed. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Analgesics: increased risk of nephrotoxicity with NSAIDs; antagonism of diuretic effect<\/li>\n
  • Anti-arrhythmics: hypokalaemia leads to increased cardiac toxicity; effects of lidocaine and mexiletine antagonised<\/li>\n
  • Antibacterials: avoid administration with lymecycline<\/li>\n
  • Antidepressants: increased risk of hypokalaemia with reboxetine; enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics<\/li>\n
  • Anti-epileptics: increased risk of hyponatraemia with carbamazepine<\/li>\n
  • Antifungals: increased risk of hypokalaemia with amphotericin Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotension with post-synaptic alpha- blockers like prazosin; hypokalaemia increases risk of ventricular arrhythmias with sotalol<\/li>\n
  • Antipsychotics: hypokalaemia increases risk of ventricular arrhythmias with amisulpride or sertindole; enhanced hypotensive effect with phenothiazines; hypokalaemia increases risk of ventricular arrhythmias with pimozide \u2013 avoid concomitant use<\/li>\n
  • Atomoxetine: hypokalaemia increases risk of ventricular arrhythmias Cardiac glycosides: increased toxicity if hypokalaemia occurs<\/li>\n
  • Ciclosporin: increased risk of nephrotoxicity and possibly hypomagnesaemia Lithium excretion reduced (increased toxicity)
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Monitor for hypokalaemia Diuresis starts within 1\u20132 hours, peaks at 4\u20136 hours and lasts for almost 24 hours Manufacturer advises to avoid in severe renal impairment due to reduced clearance<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Thiazide diuretic: Hypertension Oedema DOSE IN NORMAL RENAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2286","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2286"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2286\/revisions"}],"predecessor-version":[{"id":2308,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2286\/revisions\/2308"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}