{"id":2280,"date":"2023-06-25T17:55:36","date_gmt":"2023-06-25T17:55:36","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/vincristine-sulphate\/"},"modified":"2023-06-25T17:59:57","modified_gmt":"2023-06-25T17:59:57","slug":"vincristine-sulphate","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/vincristine-sulphate\/","title":{"rendered":"vincristine sulphate"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Antineoplastic agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

IV: 1.4\u20131.5 mg\/m2 weekly; maximum 2 mg Consult relevant local protocol<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 923<\/li>\n
  • %Protein binding                           : 75<\/li>\n
  • %Excreted unchanged in urine     :<\/li>\n
  • 10 to 20     :<\/li>\n
  • Volume of distribution (L\/kg)       : 5\u201311<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 15\u2013155\/Unchanged
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HD                     : Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Unlikely to be dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anti-epileptics: phenytoin levels may be reduced<\/li>\n
  • Antifungals: metabolism possibly inhibited by itraconazole and posaconazole (increased risk of neurotoxicity)<\/li>\n
  • Antipsychotics: avoid concomitant use with clozapine (increased risk of agranulocytosis)
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    IV<\/p>\n

    Rate of Administration<\/h4>\n

    Slow bolus<\/p>\n

    Comments<\/h4>\n

    May be administered into fast running drip of sodium chloride 0.9% or glucose 5%<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Most of an IV dose is excreted into the bile after rapid tissue binding Metabolised by cytochrome P450 (in the CYP 3A subfamily). Elimination is primarily biliary; excreted into bile and faeces (67% within 72 hours, 40\u201350% as metabolites), 10% excreted in urine in 24 hrs<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antineoplastic agent DOSE IN NORMAL RENAL FUNCTION IV:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2280","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2280"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2280\/revisions"}],"predecessor-version":[{"id":2301,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2280\/revisions\/2301"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}