{"id":2279,"date":"2023-06-25T17:55:36","date_gmt":"2023-06-25T17:55:36","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/vinblastine-sulphate\/"},"modified":"2023-06-25T18:01:51","modified_gmt":"2023-06-25T18:01:51","slug":"vinblastine-sulphate","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/vinblastine-sulphate\/","title":{"rendered":"vinblastine sulphate"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Antineoplastic agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

5.5\u20137.4 mg\/m2 (maximum of once a week) Or consult relevant local protocol<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 909.1<\/li>\n
  • %Protein binding                           : 99<\/li>\n
  • %Excreted unchanged in urine     : 14<\/li>\n
  • Volume of distribution (L\/kg)       : 13\u201340<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 25\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HD                     : Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Unlikely to be dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: toxicity increased by erythromycin \u2013 avoid concomitant use<\/li>\n
  • Anti-epileptics: phenytoin levels may be reduced<\/li>\n
  • Antifungals: metabolism possibly inhibited by posaconazole (increased risk of neurotoxicity)<\/li>\n
  • Antipsychotics: avoid concomitant use with clozapine (increased risk of agranulocytosis)
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    Add 10 mL of diluent to 10 mg vial. May be administered into fast-running drip of sodium chloride 0.9%<\/p>\n

    Route<\/h4>\n

    IV<\/p>\n

    Rate of Administration<\/h4>\n

    1 minute<\/p>\n

    Comments<\/h4>\n

    Do not dilute with large volumes (e.g. 100\u2013250 mL) or give over long periods (30\u201360 minutes) as thrombophlebitis and extravasation may occur<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Vinblastine is extensively metabolised (primarily in the liver) to desacetylvinblastine, which is more active than the parent compound. 33% of the drug is slowly excreted in the urine and 21% in the faeces within 72 hours<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antineoplastic agent DOSE IN NORMAL RENAL FUNCTION 5.5\u20137.4<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2279","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2279"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2279\/revisions"}],"predecessor-version":[{"id":2312,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2279\/revisions\/2312"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}