{"id":2278,"date":"2023-06-25T17:55:36","date_gmt":"2023-06-25T17:55:36","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/vildagliptin\/"},"modified":"2023-06-25T17:59:45","modified_gmt":"2023-06-25T17:59:45","slug":"vildagliptin","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/vildagliptin\/","title":{"rendered":"Vildagliptin"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Treatment of type 2 diabetes mellitus in combination with other antidiabetic drugs<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

With metformin or thiazolidinedione: 50 mg twice daily With a sulphonylurea: 50 mg in the morning<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 303.4<\/li>\n
  • %Protein binding                           : 9.3<\/li>\n
  • %Excreted unchanged in urine     : 23<\/li>\n
  • Volume of distribution (L\/kg)       : 71 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 3\/Increased
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Avoid<\/li>\n
  • 10 to 20     : Avoid<\/li>\n
  • <10           : Avoid
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Not dialysed. Avoid<\/li>\n
  • HD                     : Not dialysed. Avoid<\/li>\n
  • HDF\/high flux   : Not dialysed. Avoid<\/li>\n
  • CAV\/VVHD      : Not dialysed. Avoid
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • None known
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Use is contraindicated in renal impairment due to lack of data Cases of hepatic dysfunction have occasionally been reported The main metabolite (LAY 151) is removed by haemodialysis .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Treatment of type 2 diabetes mellitus in combination<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2278","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2278"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2278\/revisions"}],"predecessor-version":[{"id":2300,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2278\/revisions\/2300"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}