{"id":2275,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/venlafaxine\/"},"modified":"2023-06-25T18:04:27","modified_gmt":"2023-06-25T18:04:27","slug":"venlafaxine","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/venlafaxine\/","title":{"rendered":"Venlafaxine"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Antidepressant: Depressive illness Generalised anxiety disorders<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

37.5\u2013187.5 mg twice daily XL: 75\u2013225 mg daily Generalised anxiety disorder: 75 mg once daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 277; (313.9 as hydrochloride)<\/li>\n
  • %Protein binding                           : 27<\/li>\n
  • %Excreted unchanged in urine     : 5<\/li>\n
  • Volume of distribution (L\/kg)       : 7.5<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 5\/6\u20138 XL: 9\u201321
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    30\u201350 Dose as in normal renal function 10\u201330 Reduce total dose by 50% and administer daily<\/li>\n

  • <10           : Reduce total dose by 50% and administer daily
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     : Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      : Not dialysed. Dose as in GFR=10\u201330 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Analgesics: increased risk of bleeding with aspirin and NSAIDs<\/li>\n
  • Anticoagulants: effects of warfarin possibly enhanced<\/li>\n
  • Antidepressants: avoid concomitant use with MAOIs and moclobemide (increased risk of toxicity); possibly enhanced serotonergic effects with duloxetine<\/li>\n
  • Antimalarials: avoid concomitant use with artemether\/lumefantrine<\/li>\n
  • Antipsychotics: increases concentration of clozapine and haloperidol<\/li>\n
  • Dopaminergics: use entacapone with caution; increased risk of hypertension and CNS excitation with selegiline \u2013 avoid concomitant use<\/li>\n
  • Sibutramine: increased risk of CNS toxicity \u2013 avoid concomitant use
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Withhold dose until after haemodialysis to minimise nausea and any other side effects May be used to treat peripheral diabetic neuropathy in haemodialysis patients; dose is up to 75 mg daily. www.medscape.com\/ viewarticle\/440202 An ECG is required before treatment .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antidepressant: Depressive illness Generalised anxiety disorders DOSE IN<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2275","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2275"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2275\/revisions"}],"predecessor-version":[{"id":2324,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2275\/revisions\/2324"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}