{"id":2274,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/vecuronium-bromide\/"},"modified":"2023-06-25T18:05:26","modified_gmt":"2023-06-25T18:05:26","slug":"vecuronium-bromide","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/vecuronium-bromide\/","title":{"rendered":"vecuronium bromide"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Non-depolarising muscle relaxant<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Intubation: 80\u2013100 micrograms\/kg, with maintenance of 20\u201330 micrograms\/kg<\/p>\n

IV infusion<\/h4>\n

: 40\u2013100 micrograms\/kg bolus, followed by 48\u201384 micrograms\/kg\/hour<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 637.7<\/li>\n
  • %Protein binding                           : 30<\/li>\n
  • %Excreted unchanged in urine     : 25<\/li>\n
  • Volume of distribution (L\/kg)       : 0.18\u20130.27<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 0.5\u20131.3\/Unchanged
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HD                     : Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anaesthetics: enhanced muscle relaxant effect<\/li>\n
  • Anti-arrhythmics: procainamide enhances muscle relaxant effect<\/li>\n
  • Antibacterials: effect enhanced by aminoglycosides, clindamycin, polymyxins and piperacillin Botulinum toxin: neuromuscular block enhanced (risk of toxicity)
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    5 mL water for injection to reconstitute 10 mg vial; up to 10 mL sodium chloride 0.9% or glucose 5% may be used<\/p>\n

    Route<\/h4>\n

    IV<\/p>\n

    Rate of Administration<\/h4>\n

    See dose<\/p>\n

    Comments<\/h4>\n

    May be added to sodium chloride 0.9%, glucose 5% or Ringer\u2019s solution to give a final concentration of 40 mg\/L<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Vecuronium is largely excreted via the liver. Use normal doses with caution in renal failure as has active metabolites which may accumulate Vecuronium bromide .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Non-depolarising muscle relaxant DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2274","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2274"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2274\/revisions"}],"predecessor-version":[{"id":2334,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2274\/revisions\/2334"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}