{"id":2273,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/varenicline\/"},"modified":"2023-06-25T18:04:21","modified_gmt":"2023-06-25T18:04:21","slug":"varenicline","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/varenicline\/","title":{"rendered":"Varenicline"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Aid to smoking cessation<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

0.5 mg once daily for 3 days, 0.5 mg twice daily for 3 days, then 0.5\u20131 mg twice daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 361.3 (as tartrate)<\/li>\n
  • %Protein binding                           : <20<\/li>\n
  • %Excreted unchanged in urine     : 92<\/li>\n
  • Volume of distribution (L\/kg)       : 415 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 24\/Increased
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    Initial doses as for normal renal function, then maintenance doses of: 30\u201350 1 mg once or twice daily 10\u201330 1 mg once daily<\/li>\n

  • <10           : 0.5\u20131 mg once daily
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     : Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   : Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      : Dialysed. Dose as in GFR=10\u201330 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • None known
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013 .<\/li>\n","protected":false},"excerpt":{"rendered":"

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