{"id":2266,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ursodeoxycholic-acid\/"},"modified":"2023-06-25T18:04:00","modified_gmt":"2023-06-25T18:04:00","slug":"ursodeoxycholic-acid","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ursodeoxycholic-acid\/","title":{"rendered":"ursodeoxycholic acid"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Dissolution of gallstones Primary biliary cirrhosis<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Dissolution of gallstones: 8\u201312 mg\/kg\/day in 1\u20132 divided doses Primary biliary cirrhosis: 10\u201315 mg\/kg\/day in 2\u20134 divided doses<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 392.6<\/li>\n
  • %Protein binding                           : 96\u201398<\/li>\n
  • %Excreted unchanged in urine     : 0<\/li>\n
  • Volume of distribution (L\/kg)       : No data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : No data
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HD                     : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Ciclosporin: unpredictably increases the absorption of ciclosporin in some patients
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Completely metabolised in the liver and excreted via the faecal route<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Dissolution of gallstones Primary biliary cirrhosis DOSE IN<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2266","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2266"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2266\/revisions"}],"predecessor-version":[{"id":2321,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2266\/revisions\/2321"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}