{"id":2265,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/urokinase\/"},"modified":"2023-06-25T18:02:49","modified_gmt":"2023-06-25T18:02:49","slug":"urokinase","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/urokinase\/","title":{"rendered":"Urokinase"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Fibrinolytic agent: Thrombosed arteriovenous shunts and intravenous cannulas Treatment of thromboembolic occlusive vascular disease, e.g. DVT, PE, peripheral vascular occlusion<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Lock: 5000\u2013250 000 IU for 30 minutes \u2013 2 hours Infusion: 5000\u2013250 000 IU over 30 minutes \u2013 48 hours, depending on local protocol<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 33 000\u201354 000<\/li>\n
  • %Protein binding                           : No data<\/li>\n
  • %Excreted unchanged in urine     : Low<\/li>\n
  • Volume of distribution (L\/kg)       : No data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 20 minutes\/Increased
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Not dialysed. Dose as in normal renal function<\/li>\n
  • HD                     : Not dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Not dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • None known
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    2 mL of sodium chloride 0.9%<\/p>\n

    Route<\/h4>\n

    \u2013<\/p>\n

    Rate of Administration<\/h4>\n

    Various<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Doses from Kumwenda M, Cornall A, Corner L, et al. Urokinase for dysfunctional haemodialysis catheters. Br J Renal Med. 2005; 10(3): 10\u201311 Can also be given during dialysis Care in patients with uraemic coagulopathies or bleeding diatheses Some units mix 5000 IU with 1.5 mL heparin 1000 u\/mL .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Fibrinolytic agent: Thrombosed arteriovenous shunts and intravenous cannulas<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2265","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2265","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2265"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2265\/revisions"}],"predecessor-version":[{"id":2318,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2265\/revisions\/2318"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2265"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}