{"id":2264,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tryptophan\/"},"modified":"2023-06-25T18:04:51","modified_gmt":"2023-06-25T18:04:51","slug":"tryptophan","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tryptophan\/","title":{"rendered":"Tryptophan"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Antidepressant<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

1\u20132 g 3 times daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 204.2<\/li>\n
  • %Protein binding                           : 80<\/li>\n
  • %Excreted unchanged in urine     :<\/li>\n
  • 10 to 20     :<\/li>\n
  • Volume of distribution (L\/kg)       : 0.34\u20130.7<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 1\u20133
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Use lower doses initially
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     : Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   : Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antidepressants: possible increased serotonergic effects with duloxetine; CNS excitation and confusion with MAOIs \u2013 reduce dose of tryptophan; agitation and nausea with SSRIs<\/li>\n
  • Antimalarials: avoid concomitant administration with artemether\/ lumefantrine<\/li>\n
  • Sibutramine: increased risk of CNS toxicity \u2013 avoid concomitant use
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Associated with eosinophilia-myalgia syndrome, therefore not first line therapy .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antidepressant DOSE IN NORMAL RENAL FUNCTION 1\u20132 g<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2264","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2264"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2264\/revisions"}],"predecessor-version":[{"id":2328,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2264\/revisions\/2328"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2264"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2264"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}