{"id":2263,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tropisetron\/"},"modified":"2023-06-25T18:04:14","modified_gmt":"2023-06-25T18:04:14","slug":"tropisetron","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tropisetron\/","title":{"rendered":"Tropisetron"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Anti-emetic: Cancer chemotherapy Postoperative nausea and vomiting (PONV)<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Chemotherapy: IV bolus or infusion of 5 mg before chemotherapy, then 5 mg every morning orally for 5 days PONV: IV bolus or infusion of 2 mg before induction of anaesthesia, then 2 mg within 2 hours of the end of surgery<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 284.4 (320.8 as hydrochloride)<\/li>\n
  • %Protein binding                           : 71<\/li>\n
  • %Excreted unchanged in urine     : 8 (70% as metabolites)<\/li>\n
  • Volume of distribution (L\/kg)       : 400\u2013600 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 8\u201345 (depends on metaboliser status)\/ Increased
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HD                     : Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anti-arrhythmics: increased risk of ventricular arrhythmias \u2013 use with caution; avoid with amiodarone, disopyramide, flecainide, lidocaine, mexiletine, procainamide or propafenone<\/li>\n
  • Beta-blockers: increased risk of ventricular arrhythmias \u2013 use with caution; avoid with sotalol
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral, IV bolus,<\/p>\n

    IV infusion<\/h4>\n

    Rate of Administration<\/h4>\n

    Bolus: over at least 1 minute Infusion: over 15 minutes<\/p>\n

    Comments<\/h4>\n

    Can be added to 100 mL sodium chloride 0.9%, glucose 5% or Ringer\u2019s solution Give oral preparation at least an hour before food<\/p>\n

    OTHER INFORMATION<\/h4>\n

    In impaired kidney function, plasma concentrations of tropisetron may be increased by up to 50%, but no problem with short courses .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Anti-emetic: Cancer chemotherapy Postoperative nausea and vomiting (PONV)<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2263","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2263"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2263\/revisions"}],"predecessor-version":[{"id":2322,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2263\/revisions\/2322"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}