{"id":2260,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/trimethoprim\/"},"modified":"2023-06-25T18:04:58","modified_gmt":"2023-06-25T18:04:58","slug":"trimethoprim","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/trimethoprim\/","title":{"rendered":"Trimethoprim"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Antibacterial agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Treatment: 200 mg every 12 hours Prophylaxis: 100 mg at night<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 290.3<\/li>\n
  • %Protein binding                           : 45<\/li>\n
  • %Excreted unchanged in urine     : 40\u201360<\/li>\n
  • Volume of distribution (L\/kg)       : 1\u20132.2<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 8\u201310\/20\u201349
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    >25 Dose as in normal renal function 15\u201325 Dose as in normal renal function <15 Dose as in normal renal function<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Not dialysed. Dose as in normal renal function<\/li>\n
  • HD                     : Dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Dialysed. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Probably dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone \u2013 avoid concomitant use; concentration of procainamide increased<\/li>\n
  • Anti-epileptics: antifolate effect and concentration of phenytoin increased<\/li>\n
  • Antimalarials: increased risk of antifolate effect with pyrimethamine<\/li>\n
  • Ciclosporin: increased risk of nephrotoxicity Cytotoxics: increased risk of haematological toxicity with azathioprine and mercaptopurine; antifolate effect of methotrexate increased
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Serum creatinine may rise due to competition for renal secretion Hyperkalaemia is common in CKD 5 Short-term folic acid supplementation may be prescribed in patients with CKD 4-5 to cover antifolate effects of treatment dose .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION Treatment:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2260","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2260"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2260\/revisions"}],"predecessor-version":[{"id":2329,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2260\/revisions\/2329"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}