{"id":2258,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/triamterene\/"},"modified":"2023-06-25T18:03:30","modified_gmt":"2023-06-25T18:03:30","slug":"triamterene","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/triamterene\/","title":{"rendered":"Triamterene"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Diuretic (potassium-sparing)<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

150\u2013250 mg daily in divided doses; reduce to alternate days after 1 week<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 253<\/li>\n
  • %Protein binding                           : 60<\/li>\n
  • %Excreted unchanged in urine     : 5\u201310<\/li>\n
  • Volume of distribution (L\/kg)       : 2.2\u20133.7<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 2\/10
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Avoid. See \u2018Other Information\u2019<\/li>\n
  • <10           : Avoid. See \u2018Other Information\u2019
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Avoid<\/li>\n
  • HD                     : Unknown dialysability. Avoid<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Avoid<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Avoid
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs ACE inhibitors and angiotensin-II antagonists: enhanced hypotensive effect (risk of severe hyperkalaemia)<\/li>\n

  • Analgesics: increased risk of nephrotoxicity with NSAIDs; increased risk of hyperkalaemia, especially with indometacin; antagonism of hypotensive effect<\/li>\n
  • Antibacterials: avoid concomitant use with lymecycline<\/li>\n
  • Antidepressants: enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics<\/li>\n
  • Antipsychotics: enhanced hypotensive effect with phenothiazines Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect of post-synaptic alpha- blockers, e.g. prazosin<\/li>\n
  • Ciclosporin: increased risk of hyperkalaemia<\/li>\n
  • Lithium: reduced excretion of lithium (risk of lithium toxicity)<\/li>\n
  • Potassium salts: increased risk of hyperkalaemia<\/li>\n
  • Tacrolimus: increased risk of hyperkalaemia
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Hyperkalaemia is common when GFR<30 mL\/min. May cause acute renal failure Potassium-sparing diuretics are weak diuretics and are ineffective in moderate to severe renal failure .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Diuretic (potassium-sparing) DOSE IN NORMAL RENAL FUNCTION 150\u2013250<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2258","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2258"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2258\/revisions"}],"predecessor-version":[{"id":2319,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2258\/revisions\/2319"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}