{"id":2257,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/triamcinolone\/"},"modified":"2023-06-25T18:05:32","modified_gmt":"2023-06-25T18:05:32","slug":"triamcinolone","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/triamcinolone\/","title":{"rendered":"Triamcinolone"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Corticosteroid<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

IM: 40 mg of acetonide; maximum single dose 100 mg Intra-articular: 2.5\u201340 mg of acetonide<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 394.4 (434.5 as acetonide)<\/li>\n
  • %Protein binding                           : Low<\/li>\n
  • %Excreted unchanged in urine     : <1<\/li>\n
  • Volume of distribution (L\/kg)       : 1.4\u20132.1<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 2\u20135\/Unchanged
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HD                     : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin<\/li>\n
  • Anticoagulants: efficacy of coumarins may be altered<\/li>\n
  • Anti-epileptics: metabolism accelerated by carbamazepine, barbiturates, phenytoin and primidone<\/li>\n
  • Antifungals: increased risk of hypokalaemia with amphotericin \u2013 avoid concomitant use; metabolism possibly inhibited by itraconazole and ketoconazole<\/li>\n
  • Antivirals: concentration possibly increased by ritonavir<\/li>\n
  • Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids Cytotoxics: increased risk of haematological toxicity with methotrexate<\/li>\n
  • Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics Vaccines: high dose corticosteroids can impair immune response to vaccines; avoid concomitant use with live vaccines
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    IM, intra-articular, topical, nasal spray, intradermal<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Use with caution in severe renal impairment as sodium and water retention may occur 4 mg is equivalent to 5 mg of prednisolone .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Corticosteroid DOSE IN NORMAL RENAL FUNCTION IM: 40<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2257","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2257"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2257\/revisions"}],"predecessor-version":[{"id":2335,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2257\/revisions\/2335"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}