{"id":2256,"date":"2023-06-25T17:55:01","date_gmt":"2023-06-25T17:55:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/treosulfan\/"},"modified":"2023-06-25T18:03:42","modified_gmt":"2023-06-25T18:03:42","slug":"treosulfan","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/treosulfan\/","title":{"rendered":"Treosulfan"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Alkylating agent for ovarian cancer<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

IV: 3\u20138 g\/m 2 every 1\u20133 weeks; doses >3 g\/ m2 should be given as an infusion Doses up to 1.5 g\/m 2 have been given IP Oral: 1 g daily in 4 divided doses for 2\u20134 weeks or 1.5 g daily in 3 divided doses for 1 week Or according to local protocol<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 278.3<\/li>\n
  • %Protein binding                           : No data<\/li>\n
  • %Excreted unchanged in urine     : 22\u201330<\/li>\n
  • Volume of distribution (L\/kg)       : 44\u201388 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 1.5\u20131.94
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Use a reduced dose<\/li>\n
  • 10 to 20     : Use a reduced dose<\/li>\n
  • <10           : Use a reduced dose
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     : Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   : Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in GFR 10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • None known
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    20 or 100 mL water for injection for 1 g and 5 g vials respectively<\/p>\n

    Route<\/h4>\n

    Oral, IV, IP<\/p>\n

    Rate of Administration<\/h4>\n

    3 g\/m 2 over 5\u201310 minutes (8 g\/m2 over 30 minutes)<\/p>\n

    Comments<\/h4>\n

    Powder reconstitutes easier if water heated to 25\u201330\u00b0C<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Treosulfan is a prodrug of a bifunctional alkylating agent; high and relatively constant bioavailability. Mean urinary excretion of the parent compound is ~15% over 24 hrs Haemorrhagic cystitis has occurred after intravesical or intravenous administration .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Alkylating agent for ovarian cancer DOSE IN NORMAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2256","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2256"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2256\/revisions"}],"predecessor-version":[{"id":2320,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2256\/revisions\/2320"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2256"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}