{"id":2239,"date":"2023-06-25T17:54:34","date_gmt":"2023-06-25T17:54:34","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tiotropium\/"},"modified":"2023-06-25T18:10:25","modified_gmt":"2023-06-25T18:10:25","slug":"tiotropium","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tiotropium\/","title":{"rendered":"Tiotropium"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Maintenance treatment of chronic obstructive pulmonary disease<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

18 micrograms once daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           : 472.4 (as bromide)<\/li>\n
  • %Protein binding                           : 72<\/li>\n
  • %Excreted unchanged in urine     : 14 (of inhaled dose)<\/li>\n
  • Volume of distribution (L\/kg)       : 32<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      : 5\u20136 days\/Increased
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function. Use with caution<\/li>\n
  • <10           : Dose as in normal renal function. Use with caution
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                : Unknown dialysability. Dose as in normal renal function. Use with caution<\/li>\n
  • HD                     : Unknown dialysability. Dose as in normal renal function. Use with caution<\/li>\n
  • HDF\/high flux   : Unknown dialysability. Dose as in normal renal function. Use with caution<\/li>\n
  • CAV\/VVHD      : Unknown dialysability. Dose as in normal renal function. Use with caution
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs Avoid administration with other anti- cholinergic drugs<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Inhalation<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Not to be used for acute episodes of bronchospasm .<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Maintenance treatment of chronic obstructive pulmonary disease DOSE<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-2239","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=2239"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2239\/revisions"}],"predecessor-version":[{"id":2342,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/2239\/revisions\/2342"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=2239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=2239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=2239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}