{"id":1793,"date":"2023-06-25T17:41:44","date_gmt":"2023-06-25T17:41:44","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/didanosine\/"},"modified":"2023-06-25T19:33:53","modified_gmt":"2023-06-25T19:33:53","slug":"didanosine","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/didanosine\/","title":{"rendered":"Didanosine"},"content":{"rendered":"

<\/p>\n

Didanosine<\/h1>\n

CLINICAL USE<\/h3>\n

NSAID and analgesic<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

75\u2013150 mg daily in divided doses<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :318.1<\/li>\n
  • %Protein binding                           :99.7<\/li>\n
  • %Excreted unchanged in urine     : <1<\/li>\n
  • Volume of distribution (L\/kg)       :0.12\u20130.17<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :1\u20132\/Unchanged
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function, but avoid if possible<\/li>\n
  • <10           : Dose as in normal renal function, but only use if on dialysis
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in normal renal function.<\/li>\n
  • HD                     :Not dialysed. Dose as in normal renal function.<\/li>\n
  • HDF\/high flux   :Not dialysed. Dose as in normal renal function.<\/li>\n
  • CAV\/VVHD      :Not dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemiaAnalgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage)Antibacterials: possibly increased risk of convulsions with quinolonesAnticoagulants: effects of coumarins enhanced; possibly increased risk of bleeding with heparins and coumarins; increased risk of haemorrhage with IV diclofenac \u2013 avoid concomitant useAntidepressants: increased risk of bleeding with SSRIs and venlafaxineAntidiabetic agents: effects of sulphonylureas enhancedAnti-epileptics: possibly increased phenytoin concentrationAntivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavirCiclosporin: may potentiate nephrotoxicity; concentration increased by ciclosporinCytotoxic agents: reduced excretion of methotrexate; increased risk of bleeding with erlotinibDiuretics: increased risk of nephrotoxicity; antagonism of diuretic effect; hyperkalaemia with potassium-sparing diureticsLithium: excretion decreased Pentoxifylline: increased risk of bleeding Tacrolimus: increased risk of nephrotoxicity<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral, IV, IM, PR<\/p>\n

    Rate of Administration<\/h4>\n

    25\u201350 mg over 15\u201360 minutes; 75 mg over 30\u2013120 minutesContinuous infusion of 5 mg\/hour<\/p>\n

    Comments<\/h4>\n

    Dilute 75 mg in 100\u2013500 mL of sodium chloride 0.9% or glucose 5% buffered with 0.5 mL sodium bicarbonate 8.4%<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Diclofenac should be used with caution in uraemic patients predisposed to gastrointestinal bleeding or uraemic coagulopathiesInhibition of renal prostaglandin synthesis by NSAIDs may interfere with renal function, especially in the presence of diclofenac sodium.230 diCLoFEnAC sodiUMexisting renal disease \u2013 avoid if possible; if not, check serum creatinine 48\u201372 hours after starting NSAID \u2013 if raised, discontinue NSAID therapy. Use normal doses in patients with ERF on dialysis if they do not pass any urineUse with great caution in renal transplant recipients \u2013 can reduce intrarenal autocoid synthesis<\/li>\n","protected":false},"excerpt":{"rendered":"

    Didanosine CLINICAL USE NSAID and analgesic DOSE IN NORMAL RENAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1793","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1793"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1793\/revisions"}],"predecessor-version":[{"id":2800,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1793\/revisions\/2800"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}