{"id":1738,"date":"2023-06-25T17:40:08","date_gmt":"2023-06-25T17:40:08","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/citalopram\/"},"modified":"2023-06-25T19:42:19","modified_gmt":"2023-06-25T19:42:19","slug":"citalopram","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/citalopram\/","title":{"rendered":"Citalopram"},"content":{"rendered":"

<\/p>\n

Citalopram<\/h1>\n

CLINICAL USE<\/h3>\n

SSRI antidepressant:Depressive illness Panic disorder<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

10\u201360 mg dailyOral drops: 8\u201348 mg (4 drops = 8 mg liquid = 10 mg tablet)<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :324.4<\/li>\n
  • %Protein binding                           :<80<\/li>\n
  • %Excreted unchanged in urine     : 12<\/li>\n
  • Volume of distribution (L\/kg)       :12.3<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :36\/49.5
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function. Use with caution
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Unlikely to be dialysed. Dose as in GFR 10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsAnalgesics: increased risk of bleeding with aspirin and NSAIDs; risk of CNS toxicity increased with tramadolAnticoagulants: effect of coumarins possibly enhancedAntidepressants: avoid concomitant use with MAOIs and moclobemide, increased risk of toxicity; avoid concomitant use with St John\u2019s wort; possibly enhanced serotonergic effects with duloxetine; can increase tricyclics antidepressant concentration; increased agitation and nausea with tryptophanAnti-epileptics: convulsive threshold loweredAntimalarials: avoid concomitant use with artemether\/lumefantrineAntipsychotics: possibly increased clozapine concentrationAntivirals: concentration possibly increased by ritonavirDopaminergics: use selegiline with caution; increased risk of CNS toxicity with rasagiline5 HT 1 agonist: increased risk of CNS toxicity with sumatriptan; possibly increased risk of serotonergic effects with frovatriptanLinezolid: use with care, possibly increased risk of side effectsLithium: increased risk of CNS effects Sibutramine: increased risk of CNS toxicity (avoid concomitant use)<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    OTHER INFORMATION<\/h4>\n

    Only 1% of drug is removed by haemodialysisThere is reduced clearance of Citalopram in severe renal failure<\/li>\n","protected":false},"excerpt":{"rendered":"

    Citalopram CLINICAL USE SSRI antidepressant:Depressive illness Panic disorder DOSE IN<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1738","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1738"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1738\/revisions"}],"predecessor-version":[{"id":2851,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1738\/revisions\/2851"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}