{"id":1718,"date":"2023-06-25T17:32:51","date_gmt":"2023-06-25T17:32:51","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/cetuximab\/"},"modified":"2023-06-25T19:39:20","modified_gmt":"2023-06-25T19:39:20","slug":"cetuximab","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/cetuximab\/","title":{"rendered":"Cetuximab"},"content":{"rendered":"

<\/p>\n

Cetuximab<\/h1>\n

CLINICAL USE<\/h3>\n

Monoclonal antibody:<\/p>\n

  • Treatment of EGFR-expressing metastatic colorectal cancer in combination with irinotecan after failure of irinotecan-including cytotoxic therapy
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    Initial dose 400 mg\/m2 then 250 mg\/m2 weekly<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :152 000<\/li>\n
  • %Protein binding                           :No data<\/li>\n
  • %Excreted unchanged in urine     : minimal<\/li>\n
  • Volume of distribution (L\/kg)       :1.5\u20136.2 L\/m2<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :70\u2013100\/unchanged
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function. Use with caution<\/li>\n
  • 10 to 20     : Dose as in normal renal function. Use with caution<\/li>\n
  • <10           : Dose as in normal renal function. Use with caution
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Not dialysed. Dose as in GFR=10\u201320 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • None known
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    IV infusion<\/h4>\n

    Rate of Administration<\/h4>\n

    1st dose: 120 minutes Further doses: 60 minutes Maximum infusion rate must not exceed 5 mL\/min<\/p>\n

    Comments<\/h4>\n

    Administer via a 0.2 micrometer in-line filterThe filter may clog and need to be replaced during the infusion<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Delayed hypersensitivity reactions may occur and patients should be warned to contact their doctor if this occurs<\/li>\n
  • Premedication with an antihistamine is recommended<\/li>\n
  • 2% of patients receiving cetuximab developed renal failure<\/li>\n
  • Give irinotecan at least 1 hour after the end of cetuximab infusion.<\/li>\n","protected":false},"excerpt":{"rendered":"

    Cetuximab CLINICAL USE Monoclonal antibody: Treatment of EGFR-expressing metastatic colorectal<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1718","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1718"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1718\/revisions"}],"predecessor-version":[{"id":2822,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1718\/revisions\/2822"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}