{"id":1712,"date":"2023-06-25T17:32:51","date_gmt":"2023-06-25T17:32:51","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ceftazidime\/"},"modified":"2023-06-25T19:40:22","modified_gmt":"2023-06-25T19:40:22","slug":"ceftazidime","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ceftazidime\/","title":{"rendered":"Ceftazidime"},"content":{"rendered":"

<\/p>\n

Ceftazidime<\/h1>\n

CLINICAL USE<\/h3>\n

Antibacterial agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

0.5\u20132 g every 8\u201312 hours Severe infections: 3 g every 12 hours Pseudomonal lung infections in cystic fibrosis: 100\u2013150 mg\/kg in 3 divided dosesSurgical prophylaxis: 1 g at induction<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :637.7<\/li>\n
  • %Protein binding                           :<\/li>\n
  • <10           :<\/li>\n
  • %Excreted unchanged in urine     : 80\u201390<\/li>\n
  • Volume of distribution (L\/kg)       :0.28\u20130.4<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :2\/13\u201325
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    31\u201350 1\u20132 g every 12 hours16\u201330 1\u20132 g every 24 hours6\u201315 500 mg \u2013 1 g every 24 hours<5 500 mg \u2013 1 g every 48 hours<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Dialysed. 500 mg \u2013 1 g every 24 hours<\/li>\n
  • HD                     :Dialysed. 500 mg \u2013 1 g every 24\u201348 hours<\/li>\n
  • HDF\/high flux   :Dialysed. 500 mg \u2013 1 g every 24\u201348 hours<\/li>\n
  • CAV\/VVHD      :Dialysed. 2 g every 8 hours1 or 1\u20132 g every 12 hours1,2,3CVVhd\/HDFDialysed. 2 g every 12 hours3
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anticoagulants: effects of coumarins may be enhanced<\/li>\n
  • Ciclosporin: may cause increased ciclosporin levels
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n<\/li>\n
  • Amount of water for injection to be added to vials:<\/li>\n
  • 1.5 mL to 500 mg vial for IM administration<\/li>\n
  • 5 mL to 500 mg vial for IV injection<\/li>\n
  • 3 mL to 1 g vial for IM administration<\/li>\n
  • 10 mL to 1 g vial for IV injection \u2014
    \n

    Route<\/h4>\n

    IV\/IM rarely<\/p>\n

    Rate of Administration<\/h4>\n

    Bolus: 3\u20134 minutes Infusion: over 30 minutes<\/p>\n

    Comments<\/h4>\n

    May be given IP in fluid 50\u2013125 mg\/L fluid<\/li>\n

  • Reconstituted solutions vary in colour, but this is quite normal<\/li>\n
  • Compatible with most IV fluids, e.g. sodium chloride 0.9%, glucose-saline, glucose 5%
    \n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Volume of distribution increases with infection<\/li>\n
  • In exceptional circumstances, patients on haemodialysis may be given a dose of 2 g, 3 times a week post HD<\/li>\n","protected":false},"excerpt":{"rendered":"

    Ceftazidime CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1712","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1712"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1712\/revisions"}],"predecessor-version":[{"id":2829,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1712\/revisions\/2829"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}