{"id":1711,"date":"2023-06-25T17:32:51","date_gmt":"2023-06-25T17:32:51","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/cefradine\/"},"modified":"2023-06-25T19:40:46","modified_gmt":"2023-06-25T19:40:46","slug":"cefradine","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/cefradine\/","title":{"rendered":"Cefradine"},"content":{"rendered":"

<\/p>\n

Cefradine<\/h1>\n

CLINICAL USE<\/h3>\n

Antibacterial agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Oral: 250\u2013500 mg every 6 hours (or 500 mg \u2013 1 g every 12 hours)Severe infections: 1 g every 6 hoursInjection: 0.5\u20132 g every 6 hoursSurgical prophylaxis: 1\u20132 g at induction<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :349.4<\/li>\n
  • %Protein binding                           :8\u201312<\/li>\n
  • %Excreted unchanged in urine     : >90<\/li>\n
  • Volume of distribution (L\/kg)       :0.25\u20130.46<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :1\/6\u201315
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : 250\u2013500 mg every 6 hours
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • HD                     :Dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • HDF\/high flux   :Dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • CAV\/VVHD      :Dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    IM: 2 mL of water for injection or sodium chloride 0.9% to each 500 mg<\/li>\n

  • IV bolus: 5 mL of water for injection, sodium chloride 0.9% or glucose 5% to each 500 mg<\/li>\n
  • IV infusions: 10 mL of suitable diluent to 1 g vial then add to infusion solution
    \n

    Route<\/h4>\n

    Oral, IM, IV<\/p>\n

    Rate of Administration<\/h4>\n

    IV bolus: over 3\u20135 minutes<\/p>\n

    Comments<\/h4>\n<\/li>\n","protected":false},"excerpt":{"rendered":"

    Cefradine CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1711","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1711"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1711\/revisions"}],"predecessor-version":[{"id":2831,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1711\/revisions\/2831"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}