{"id":1698,"date":"2023-06-25T17:31:27","date_gmt":"2023-06-25T17:31:27","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/capreomycin\/"},"modified":"2023-06-25T19:47:40","modified_gmt":"2023-06-25T19:47:40","slug":"capreomycin","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/capreomycin\/","title":{"rendered":"Capreomycin"},"content":{"rendered":"

<\/p>\n

Capreomycin<\/h1>\n

CLINICAL USE<\/h3>\n

Antibacterial agent in combination with other drugs:<\/p>\n

  • Tuberculosis that is resistant to first-line drugs
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    Deep IM injection: 1 g daily (not more than 20 mg\/kg) for 2\u20134 months, then 1 g 2\u20133 times each week<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :668.7<\/li>\n
  • %Protein binding                           :No data<\/li>\n
  • %Excreted unchanged in urine     : 50<\/li>\n
  • Volume of distribution (L\/kg)       :0.37\u20130.42<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :2\/55.5
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : 1 g every 48 hours
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • HDF\/high flux   :Dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • CAV\/VVHD      :Not dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsIncreased risk of nephrotoxicity and ototoxicity with aminoglycosides and vancomycin<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    Dissolve in 2 mL of sodium chloride 0.9% or water for injection. 2\u20133 minutes should be allowed for complete dissolution<\/p>\n

    Route<\/h4>\n

    Deep IM injection<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Nephrotoxic Check potassium levels as hypokalaemia may occur<\/li>\n
  • Desired steady state serum capreomycin level is 10 micrograms\/mLDose should not exceed 1 g\/day in renal failure<\/li>\n
  • Capreomycin sulphate 1 000 000 Units approximately equivalent to capreomycin base 1 g<\/li>\n","protected":false},"excerpt":{"rendered":"

    Capreomycin CLINICAL USE Antibacterial agent in combination with other drugs:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1698","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1698","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1698"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1698\/revisions"}],"predecessor-version":[{"id":2827,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1698\/revisions\/2827"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1698"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1698"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}