{"id":1697,"date":"2023-06-25T17:31:27","date_gmt":"2023-06-25T17:31:27","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/capecitabine\/"},"modified":"2023-06-25T19:45:56","modified_gmt":"2023-06-25T19:45:56","slug":"capecitabine","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/capecitabine\/","title":{"rendered":"Capecitabine"},"content":{"rendered":"

<\/p>\n

Capecitabine<\/h1>\n

CLINICAL USE<\/h3>\n

Antineoplastic agent (antimetabolite):<\/p>\n

  • Colorectal, colon and breast cancer
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    1.25 g\/m2 twice daily for 14 days, repeated after 7 days<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :359.4<\/li>\n
  • %Protein binding                           :54<\/li>\n
  • %Excreted unchanged in urine     : 3<\/li>\n
  • Volume of distribution (L\/kg)       :No data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :0.85\/Increased
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    30\u201350 75% of dose (950 mg\/m2 twice daily) use with care10\u201330 Avoid<\/li>\n

  • <10           : Avoid
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in GFR=10\u201330 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Allopurinol: avoid concomitant use<\/li>\n
  • Anticoagulants: possibly enhances effect of coumarins<\/li>\n
  • Anti-epileptics: reported toxicity with phenytoin, due to increased phenytoin levels<\/li>\n
  • Antipsychotics: avoid concomitant use with clozapine \u2013 increased risk of agranulocytosis
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    Give after food<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Capecitabine is a prodrug that is metabolised to fluorouracil<\/li>\n
  • Contraindicated in severe renal impairment due to increased incidence of grade 3 or 4 adverse reactions in patients with GFR of 30\u201350 mL\/min<\/li>\n
  • Extensive absorption (~70%) after food intake.<\/li>\n
  • First metabolised in the liver and then in the tumour. Up to 96% dose is recovered in the urine. Terminal T\u00bd = 0.85 hours<\/li>\n","protected":false},"excerpt":{"rendered":"

    Capecitabine CLINICAL USE Antineoplastic agent (antimetabolite): Colorectal, colon and breast<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1697","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1697","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1697"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1697\/revisions"}],"predecessor-version":[{"id":2860,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1697\/revisions\/2860"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1697"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1697"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}