{"id":1694,"date":"2023-06-25T17:31:27","date_gmt":"2023-06-25T17:31:27","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/calcium-gluconate\/"},"modified":"2023-06-25T19:45:27","modified_gmt":"2023-06-25T19:45:27","slug":"calcium-gluconate","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/calcium-gluconate\/","title":{"rendered":"Calcium gluconate"},"content":{"rendered":"

<\/p>\n

Calcium gluconate<\/h1>\n

CLINICAL USE<\/h3>\n

Hypocalcaemia<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Depending on indication<\/p>\n

  • Acute hypocalcaemia:<\/li>\n
  • 10 to 20     : mL calcium gluconate 10% (2.25\u20134.5 mmol calcium) slow<\/li>\n
  • IV injection over 3\u201310 minutes<\/li>\n
  • Oral: Dose varies depending on requirements
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :448.4<\/li>\n
  • %Protein binding                           :\u2013<\/li>\n
  • %Excreted unchanged in urine     : \u2013<\/li>\n
  • Volume of distribution (L\/kg)       :\u2013<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function. Titrate to response<\/li>\n
  • 10 to 20     : Dose as in normal renal function. Titrate to response<\/li>\n
  • <10           : Dose as in normal renal function. Titrate to response
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Dialysed. Dose as in normal renal function<\/li>\n
  • HD                     :Dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :Dialysed. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      :Dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Can impair absorption of some drugs, e.g. iron, ciprofloxacin
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral, IV, IM<\/p>\n

    Rate of Administration<\/h4>\n

    IV: slow 3\u20134 minutes for each 10 mL (2.25 mmol calcium); not greater than 20 mmol\/hour for continuous infusions<\/p>\n

    Comments<\/h4>\n

    IV: Can be used undiluted for continuous and intermittent infusions<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Check patient\u2019s magnesium levels<\/li>\n
  • Monitor calcium and PO 4 serum levels<\/li>\n
  • Calcium-Sandoz 400: 10 mmol calcium per tablet<\/li>\n
  • Calcium-Sandoz 1000: 25 mmol calcium per tablet<\/li>\n
  • Calcium levels cannot be corrected until magnesium levels are normal<\/li>\n","protected":false},"excerpt":{"rendered":"

    Calcium gluconate CLINICAL USE Hypocalcaemia DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1694","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1694"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1694\/revisions"}],"predecessor-version":[{"id":2857,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1694\/revisions\/2857"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}