{"id":1690,"date":"2023-06-25T17:31:27","date_gmt":"2023-06-25T17:31:27","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/calcitonin\/"},"modified":"2023-06-25T17:31:27","modified_gmt":"2023-06-25T17:31:27","slug":"calcitonin","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/calcitonin\/","title":{"rendered":"Calcitonin"},"content":{"rendered":"

<\/p>\n

Calcitonin<\/h1>\n

CLINICAL USE <\/H3><\/p>\n
  • Hypercalcaemia of malignancy\n
  • Paget\u2019s disease of bone\n
  • Post-menopausal osteoporosis\n
  • Prevention of acute bone loss due to sudden immobility

    DOSE IN NORMAL RENAL FUNCTION <\/H3>\n
  • Hypercalcaemia of malignancy: 100\u2013400 units every 6\u20138 hours (SC\/IM); in severe or emergency situation, up to 10 units\/kg by IV infusion\n
  • Paget\u2019s disease of bone: 50 units 3 times a week to 100 units daily (SC\/IM)\n
  • Post-menopausal osteoporosis: 200 units (1 spray) into 1 nostril daily with calcium and vitamin D supplements\n
  • Prevention of acute bone loss due to sudden immobility: 100 units daily in 1\u20132 divided doses for 2\u20134 weeks then reduce to 50 units daily until fully mobile (SC\/IM)

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :3431.9<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :30\u201340<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : Minimal<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :9.9 litres<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :50\u201390 minutes (parenteral); 16\u201343 minutes (intranasal)\/Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • None known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Intranasal, IM, IV, SC

    Rate of Administration <\/H4>Over at least 6 hours

    Comments<\/H4>Dilute in 500 ml sodium chloride 0.9% and administer immediately; dilution may result in a loss of potency

    OTHER INFORMATION <\/H4>\n
  • Peak plasma concentration occurs 30\u2013 40 minutes after intranasal administration, and 15\u201325 minutes after parenteral administration\n
  • Mainly GI side effects
    \n","protected":false},"excerpt":{"rendered":"

    Calcitonin CLINICAL USE Hypercalcaemia of malignancy Paget\u2019s disease of bone<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1690","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1690","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1690"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1690\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1690"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1690"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1690"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}