{"id":1689,"date":"2023-06-25T17:31:26","date_gmt":"2023-06-25T17:31:26","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/cabergoline\/"},"modified":"2023-06-25T19:50:52","modified_gmt":"2023-06-25T19:50:52","slug":"cabergoline","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/cabergoline\/","title":{"rendered":"Cabergoline"},"content":{"rendered":"

<\/p>\n

Cabergoline<\/h1>\n

CLINICAL USE<\/h3>\n
  • Endocrine disorders<\/li>\n
  • Adjunct to levodopa (with a decarboxylase inhibitor) in Parkinson\u2019s disease<\/li>\n
  • Inhibition\/suppression of lactation
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n<\/li>\n
  • Parkinson\u2019s disease: 2\u20136 mg daily<\/li>\n
  • Hyperprolactinaemic disorders: 0.25\u20132 mg weekly<\/li>\n
  • Inhibition of lactation: single 1 mg dose during first day post partum<\/li>\n
  • Suppression of lactation: 0.25 mg twice a day for 2 days
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :451.6<\/li>\n
  • %Protein binding                           :41\u201342<\/li>\n
  • %Excreted unchanged in urine     : 2\u20133<\/li>\n
  • Volume of distribution (L\/kg)       :No data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :63\u201368 (healthy individuals), 79\u2013115 (hyperprolactinaemic individuals)\/Unchanged
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Dialysed. Dose as in normal renal function<\/li>\n
  • HD                     :Dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :Dialysed. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      :Dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • None known
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • 18% of radiolabelled dose is excreted as inactive metabolites in urine72% of dose is excreted in faeces<\/li>\n","protected":false},"excerpt":{"rendered":"

    Cabergoline CLINICAL USE Endocrine disorders Adjunct to levodopa (with a<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1689","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1689"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1689\/revisions"}],"predecessor-version":[{"id":2901,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1689\/revisions\/2901"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}