{"id":1687,"date":"2023-06-25T17:31:26","date_gmt":"2023-06-25T17:31:26","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/buspirone-hydrochloride\/"},"modified":"2023-06-25T19:48:24","modified_gmt":"2023-06-25T19:48:24","slug":"buspirone-hydrochloride","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/buspirone-hydrochloride\/","title":{"rendered":"Buspirone hydrochloride"},"content":{"rendered":"

<\/p>\n

Buspirone hydrochloride<\/h1>\n

CLINICAL USE<\/h3>\n

Anxiolytic<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n
  • Initially 5 mg 2\u20133 times daily.<\/li>\n
  • Usual range 15\u201330 mg daily in divided doses (maximum 45 mg daily)
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :422<\/li>\n
  • %Protein binding                           :95<\/li>\n
  • %Excreted unchanged in urine     : 0<\/li>\n
  • Volume of distribution (L\/kg)       :2.69\u20137.91<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :2\u201311\/Increased by 2 hours1
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Reduce by 25\u201350% if patient is anuric2
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Not dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: concentration increased by erythromycin \u2013 reduce dose; concentration reduced by rifampicin<\/li>\n
  • Antidepressants: risk of severe hypertension with MAOIs \u2013 avoid concomitant use<\/li>\n
  • Antifungals: concentration increased by itraconazole \u2013 reduce dose<\/li>\n
  • Antipsychotics: enhanced sedative effects; haloperidol concentration increased<\/li>\n
  • Antivirals: concentration increased by ritonavir, increased risk of toxicity<\/li>\n
  • Calcium-channel blockers: concentration increased by diltiazem and verapamil \u2013 reduce dose<\/li>\n
  • Grapefruit juice: concentration increased by grapefruit juice \u2013 reduce dose
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Peak plasma levels occur 60\u201390 minutes after dosing<\/li>\n
  • Steady state plasma concentrations achieved within 2 days, although response to treatment may take 2 weeks<\/li>\n
  • Non-sedative Do not use in patients with severe hepatic disease<\/li>\n
  • Use in severe renal impairment not recommended; risk of accumulation of active metabolites<\/li>\n","protected":false},"excerpt":{"rendered":"

    Buspirone hydrochloride CLINICAL USE Anxiolytic DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1687","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1687","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1687"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1687\/revisions"}],"predecessor-version":[{"id":2877,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1687\/revisions\/2877"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1687"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1687"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1687"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}