{"id":1686,"date":"2023-06-25T17:31:26","date_gmt":"2023-06-25T17:31:26","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/bupropion-hydrochloride\/"},"modified":"2023-06-25T19:48:11","modified_gmt":"2023-06-25T19:48:11","slug":"bupropion-hydrochloride","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/bupropion-hydrochloride\/","title":{"rendered":"Bupropion hydrochloride"},"content":{"rendered":"

<\/p>\n

Bupropion hydrochloride<\/h1>\n

CLINICAL USE<\/h3>\n

Adjunct to smoking cessation<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

150 mg once daily for 6 days, then twice daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :276.2<\/li>\n
  • %Protein binding                           :84<\/li>\n
  • %Excreted unchanged in urine     : 0.5<\/li>\n
  • Volume of distribution (L\/kg)       :2000 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :14\u201320
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : 150 mg daily<\/li>\n
  • 10 to 20     : 150 mg daily<\/li>\n
  • <10           : 150 mg daily
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Unlikely to be dialysed. Dose as in GFR 10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antidepressants: avoid MAOIs and linezolid with and for 2 weeks before starting treatment; avoid concomitant treatment with moclobemide; possibly increased citalopram concentration<\/li>\n
  • Antivirals: concentration increased by ritonavir, risk of toxicity \u2013 avoid concomitant use<\/li>\n
  • Ciclosporin: may reduce ciclosporin levels
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Bupropion and metabolites may accumulate in renal failure<\/li>\n","protected":false},"excerpt":{"rendered":"

    Bupropion hydrochloride CLINICAL USE Adjunct to smoking cessation DOSE IN<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1686","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1686"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1686\/revisions"}],"predecessor-version":[{"id":2876,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1686\/revisions\/2876"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}