{"id":1683,"date":"2023-06-25T17:31:26","date_gmt":"2023-06-25T17:31:26","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/budesonide\/"},"modified":"2023-06-25T19:46:14","modified_gmt":"2023-06-25T19:46:14","slug":"budesonide","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/budesonide\/","title":{"rendered":"Budesonide"},"content":{"rendered":"

<\/p>\n

Budesonide<\/h1>\n

CLINICAL USE<\/h3>\n
  • Asthma<\/li>\n
  • Allergic and vasomotor rhinitis<\/li>\n
  • Inflammatory skin disorders
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    Inhaler\/Turbohaler: 200\u20131600 micrograms daily in divided doses<\/li>\n

  • Respules: 1\u20132 mg twice daily; half doses for maintenance<\/li>\n
  • Nasal spray: 100 micrograms each nostril twice daily or 200 micrograms each nostril once daily; reduce to 100 micrograms each nostril once daily when symptoms controlled<\/li>\n
  • Topical preparations: apply 1\u20132 times daily<\/li>\n
  • Capsules: 3 mg, 3 times a day, CR: 9 mg once dailycinEnema: 2 mg\/100 mL at bedtime
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :430.5<\/li>\n
  • %Protein binding                           :85\u201390<\/li>\n
  • %Excreted unchanged in urine     : 0<\/li>\n
  • Volume of distribution (L\/kg)       :3<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :1.8\u20132.2 (inhaled), 3\u20134 (oral)\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HD                     :Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :Unlikely to be dialysed. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      :Unlikely to be dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antifungals: concentration of inhaled budesonide increased by itraconazole and ketoconazole<\/li>\n
  • Antivirals: concentration of inhaled and intranasal budesonide increased by ritonavir
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    Respules: may be diluted up to 50% with sterile sodium chloride 0.9%<\/p>\n

    Route<\/h4>\n

    Inhalation, topical, oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Special care is needed in patients with quiescent lung tuberculosis, fungal and viral infections in the airways.<\/li>\n","protected":false},"excerpt":{"rendered":"

    Budesonide CLINICAL USE Asthma Allergic and vasomotor rhinitis Inflammatory skin<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1683","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1683"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1683\/revisions"}],"predecessor-version":[{"id":2861,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1683\/revisions\/2861"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}