{"id":1682,"date":"2023-06-25T17:31:26","date_gmt":"2023-06-25T17:31:26","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/bromocriptine\/"},"modified":"2023-06-25T19:46:21","modified_gmt":"2023-06-25T19:46:21","slug":"bromocriptine","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/bromocriptine\/","title":{"rendered":"Bromocriptine"},"content":{"rendered":"

<\/p>\n

Bromocriptine<\/h1>\n

CLINICAL USE<\/h3>\n
  • Parkinsonism (but not drug-induced extrapyramidal symptoms)<\/li>\n
  • Endocrine disorders
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n<\/li>\n
  • Parkinson\u2019s disease: Week 1: 1\u20131.25 mg at night \u2014Week 2: 2\u20132.5 mg at night \u2014Week 3: 2.5 mg twice daily \u2014Week 4: 2.5 mg, 3 times daily \u2014then increasing by 2.5 mg every \u20143\u201314 days according to response \u2013 usual range 10\u201340 mg daily<\/li>\n
  • Hypogonadism\/galactorrhoea, infertility: 1\u20131.25 mg at night, increased gradually; usual dose 7.5 mg daily in divided doses (maximum 30 mg daily); infertility without hyperprolactinaemia: 2.5 mg twice daily<\/li>\n
  • Cyclical benign breast disease and cyclical menstrual disorders: 1\u20131.25 mg at night increased gradually; usual dose 2.5 mg twice daily<\/li>\n
  • Acromegaly: 1\u20131.25 mg at night increased gradually to 5 mg every 6 hours<\/li>\n
  • Prolactinoma: 1\u20131.25 mg at night increased gradually to 5 mg every 6 hours (maximum 30 mg daily)
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :750.7 (as mesilate)<\/li>\n
  • %Protein binding                           :90\u201396<\/li>\n
  • %Excreted unchanged in urine     : 2.5\u20135.5<\/li>\n
  • Volume of distribution (L\/kg)       :1\u20133<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :8\u201320\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in normal renal function<\/li>\n
  • HD                     :Not dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      :Not dialysed. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsIncreased risk of toxicity with bromocriptine and isometheptene or phenylpropanolamine<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    Take with food<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Hypotensive reactions may occur during the first few days of treatment. Tolerance may be reduced by alcoholDigital vasospasm can occur<\/li>\n
  • Concomitant administration of macrolide antibiotics may elevate bromocriptine levels.<\/li>\n","protected":false},"excerpt":{"rendered":"

    Bromocriptine CLINICAL USE Parkinsonism (but not drug-induced extrapyramidal symptoms) Endocrine<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1682","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1682"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1682\/revisions"}],"predecessor-version":[{"id":2862,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1682\/revisions\/2862"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}