{"id":1676,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/bisoprolol-fumarate\/"},"modified":"2023-06-25T19:47:09","modified_gmt":"2023-06-25T19:47:09","slug":"bisoprolol-fumarate","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/bisoprolol-fumarate\/","title":{"rendered":"Bisoprolol fumarate"},"content":{"rendered":"

<\/p>\n

Bisoprolol fumarate<\/h1>\n

CLINICAL USE<\/h3>\n

Beta-1 adrenoceptor blocker:cinHypertension, angina<\/p>\n

  • Adjunctive treatment for heart failure
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    5\u201320 mg dailyHeart failure: 1.25 mg daily increasing to 10 mg daily<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :767<\/li>\n
  • %Protein binding                           :30<\/li>\n
  • %Excreted unchanged in urine     : 50<\/li>\n
  • Volume of distribution (L\/kg)       :3.5<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :9\u201312\/18\u201324
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in normal renal function<\/li>\n
  • HD                     :Not dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anaesthetics: enhanced hypotensive effect<\/li>\n
  • Analgesics: NSAIDs antagonise hypotensive effect<\/li>\n
  • Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone<\/li>\n
  • Antibacterials: concentration reduced by rifampicin<\/li>\n
  • Antidepressants: enhanced hypotensive effect with MAOIs<\/li>\n
  • Antihypertensives: enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin<\/li>\n
  • Antimalarials: increased risk of bradycardia with mefloquine<\/li>\n
  • Antipsychotics: enhanced hypotensive effect with phenothiazines<\/li>\n
  • Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil<\/li>\n
  • Diuretics: enhanced hypotensive effect Moxisylyte: possible severe postural hypotension<\/li>\n
  • Sympathomimetics: severe hypertension with adrenaline and noradrenaline, and possibly with dobutamine
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Use with caution in patients with chronic obstructive airways disease, asthma or diabetes<\/li>\n","protected":false},"excerpt":{"rendered":"

    Bisoprolol fumarate CLINICAL USE Beta-1 adrenoceptor blocker:cinHypertension, angina Adjunctive treatment<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1676","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1676"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1676\/revisions"}],"predecessor-version":[{"id":2868,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1676\/revisions\/2868"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1676"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1676"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}