{"id":1675,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/bisacodyl\/"},"modified":"2023-06-25T19:50:29","modified_gmt":"2023-06-25T19:50:29","slug":"bisacodyl","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/bisacodyl\/","title":{"rendered":"Bisacodyl"},"content":{"rendered":"

<\/p>\n

Bisacodyl<\/h1>\n

CLINICAL USE<\/h3>\n

Laxative<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Oral: 5\u201310 mg at nightRectal: 10 mg in the morningBowel evacuation:<\/p>\n

  • 10 to 20     : mg orally at night followed by 10 mg as suppositories the next morning
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :361.4<\/li>\n
  • %Protein binding                           :Negligible<\/li>\n
  • %Excreted unchanged in urine     : 30<\/li>\n
  • Volume of distribution (L\/kg)       :<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HD                     :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsNone known<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral, rectal<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Absorption is <5% orally or rectally<\/li>\n
  • Rapidly converted in the gut (by intestinal and bacterial enzymes) to its active, but non-absorbed, desacetyl metabolite<\/li>\n","protected":false},"excerpt":{"rendered":"

    Bisacodyl CLINICAL USE Laxative DOSE IN NORMAL RENAL FUNCTION Oral:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1675","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1675"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1675\/revisions"}],"predecessor-version":[{"id":2894,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1675\/revisions\/2894"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}