{"id":1672,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/bevacizumab1\/"},"modified":"2023-06-25T19:50:04","modified_gmt":"2023-06-25T19:50:04","slug":"bevacizumab1","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/bevacizumab1\/","title":{"rendered":"Bevacizumab1"},"content":{"rendered":"

<\/p>\n

Bevacizumab<\/h1>\n

CLINICAL USE<\/h3>\n

Treatment of metastatic carcinoma of the colon or rectum<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

5 mg\/kg every 14 days<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :149 000<\/li>\n
  • %Protein binding                           :No data<\/li>\n
  • %Excreted unchanged in urine     : No data<\/li>\n
  • Volume of distribution (L\/kg)       :0.046<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :11\u201350 days (average 20 days)
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Use with caution<\/li>\n
  • 10 to 20     : Use with caution<\/li>\n
  • <10           : Use with caution
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Use with caution. See \u2018Other Information\u2019<\/li>\n
  • HD                     :Not dialysed. Use with caution. See \u2018Other Information\u2019<\/li>\n
  • HDF\/high flux   :Not dialysed. Use with caution. See \u2018Other Information\u2019<\/li>\n
  • CAV\/VVHD      :Not dialysed. Use with caution. See \u2018Other Information\u2019
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsNone known<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    IV infusion<\/h4>\n

    Rate of Administration<\/h4>\n

    30\u201390 minutes depending on how the patient tolerates it<\/p>\n

    Comments<\/h4>\n

    Dilute in 100 mL of sodium chloride 0.9% DO NOT mix with glucose solutions<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Increased incidence of hypertension has been seen with treatment<\/li>\n
  • People with a history of hypertension may be at an increased risk of proteinuria.<\/li>\n
  • Discontinue therapy in patients with Grade 4 proteinuria (nephrotic syndrome)<\/li>\n
  • Can delay wound healing Bevacizumab has been used in a haemodialysis patient at a dose of 5 mg\/kg every 14 days.<\/li>\n","protected":false},"excerpt":{"rendered":"

    Bevacizumab CLINICAL USE Treatment of metastatic carcinoma of the colon<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1672","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1672","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1672"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1672\/revisions"}],"predecessor-version":[{"id":2891,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1672\/revisions\/2891"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1672"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1672"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1672"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}